1.14.18.9: 4alpha-methylsterol monooxygenase
This is an abbreviated version!
For detailed information about 4alpha-methylsterol monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.9
-
1.14.18.9
-
ergosterol
-
lanosterol
-
4,4-dimethylzymosterol
-
erg27p
-
psoriasiform
-
smith-lemli-opitz
-
meiosis-activating
-
methylsterols
-
medicine
-
agriculture
- 1.14.18.9
- ergosterol
- lanosterol
- 4,4-dimethylzymosterol
- erg27p
-
psoriasiform
-
smith-lemli-opitz
-
meiosis-activating
-
methylsterols
- medicine
- agriculture
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
4,4-dimethyl-sterol 4alpha-methyl-oxidase, 4,4-dimethyl-zymosterol 4alpha-methyl-oxidase, 4-methyl sterol oxidase, 4-methylsterol oxidase, C-4 methyl sterol oxidase, C-4 sterol methyl oxidase, EC 1.14.13.72, EC 1.14.99.16, ERG25, ERG25p, GintSMO protein, methyl sterol oxidase, methylsterol hydroxylase, methylsterol monooxygenase, NAD(P)H-dependent methylsterol oxidase, SC4MOL, SMO, sterol C-4 methyloxidase, sterol C4 methyl oxidase, sterol-C4-methyl oxidase, sterol-C4-methyl-oxidase
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 1.14.18.9 - 4alpha-methylsterol monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + a ferricytochrome + H2O
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + CO2
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + H2O
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + 3 reduced acceptor + 3 O2
(3beta,4alpha)-3-hydroxy-4-methylcholesta-8,14-24-triene-4-carboxylate + 3 acceptor + 3 H2O
-
-
-
-
?
4,4-dimethyl-zymosterol + reduced acceptor + O2
4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
4,4-dimethyl-zymosterol + reduced acceptor + O2
?
-
artificial substrate
-
-
?
4,4-[30,31-14C]dimethyl-5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
?
-
-
-
-
?
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
?
-
-
-
-
?
4alpha[30-3H]-methyl-5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
?
-
-
-
-
?
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferricytochrome + H2O
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + a ferricytochrome + H2O
-
step 3 of 3 of the overall reaction
-
-
?
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + a ferricytochrome + H2O
-
step 3 of 3 of the overall reaction
-
-
?
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + CO2
-
-
-
-
?
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + CO2
-
-
products of two step hydroxylase and demethylase activity, labile intermediate 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol and 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol
?
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + CO2
-
-
-
-
?
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + H2O
-
step 1 of 3 of the overall reaction
-
-
?
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + H2O
-
step 1 of 3 of the overall reaction
-
-
?
4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
-
-
-
-
?
4,4-dimethyl-zymosterol + reduced acceptor + O2
4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
-
a step in the ergosterol biosynthesis, pathway, overview
-
-
?
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferricytochrome + H2O
-
step 2 of 3 of the overall reaction
-
-
?
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferricytochrome + H2O
-
step 2 of 3 of the overall reaction
-
-
?
?
-
-
the enzyme is involved in cholesterol biosynthesis, (24S)-hydroxycholesterol downregulates cholesterol synthesis in neurons, possibly, in a posttranscriptional manner through SREBP-2, overview
-
-
?
additional information
?
-
squalene is sterol precursor, 24-methyl and 24-ethyl cholesterol are major sterol compounds in arbuscular mycorrhizal fungi, biosynthetic intermediates are lanosterol and 24-methylene lanosterol
-
-
?
additional information
?
-
-
squalene is sterol precursor, 24-methyl and 24-ethyl cholesterol are major sterol compounds in arbuscular mycorrhizal fungi, biosynthetic intermediates are lanosterol and 24-methylene lanosterol
-
-
?
additional information
?
-
-
enzyme is a key enzyme in ergosterol biosynthetic pathway in fungi, determination and analysis of sterol content in wild-type and mutant strains
-
-
?
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis as component of the sterol-4-demethylation multienzyme complex, sterol metabolites analysis, overview
-
-
?
additional information
?
-
-
substrate specificity, 24-methylene-24-dihydrocycloartenol is a poor substrate, no activity with 24-ethylidene-24-dihydrolophenol, overview
-
-
?
additional information
?
-
-
the enzyme is closely associated to Erg28p
-
-
?
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis as component of the sterol-4-demethylation multienzyme complex, sterol metabolites analysis, overview
-
-
?
additional information
?
-
-
substrate specificity, 24-methylene-24-dihydrocycloartenol is a poor substrate, no activity with 24-ethylidene-24-dihydrolophenol, overview
-
-
?