1.14.18.9: 4alpha-methylsterol monooxygenase

This is an abbreviated version!
For detailed information about 4alpha-methylsterol monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.9

1.14.18.9

ergosterol

lanosterol

4,4-dimethylzymosterol

erg27p

psoriasiform

smith-lemli-opitz

meiosis-activating

methylsterols

medicine

agriculture

Reaction

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde

+ 2 ferrocytochrome b5 +

+ 2 H+ =

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate

+ 2 ferricytochrome b5 +

Synonyms

4,4-dimethyl-sterol 4alpha-methyl-oxidase, 4,4-dimethyl-zymosterol 4alpha-methyl-oxidase, 4-methyl sterol oxidase, 4-methylsterol oxidase, C-4 methyl sterol oxidase, C-4 sterol methyl oxidase, EC 1.14.13.72, EC 1.14.99.16, ERG25, ERG25p, GintSMO protein, methyl sterol oxidase, methylsterol hydroxylase, methylsterol monooxygenase, NAD(P)H-dependent methylsterol oxidase, SC4MOL, SMO, sterol C-4 methyloxidase, sterol C4 methyl oxidase, sterol-C4-methyl oxidase, sterol-C4-methyl-oxidase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

1.14.18.9 4alpha-methylsterol monooxygenase

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Results	in table
112	AA Sequence
2	Application
1	CAS Registry Number
4	Cloned(Commentary)
10	Cofactor
62	Disease/ Diagnostics
4	General Information
8	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
18	Localization
1	Metals/Ions
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
182	Organism
9	Pathway
2	pI Value
3	Posttranslational Modification
7	Protein Variants
4	Purification (Commentary)
7	Reaction
3	Reaction Type
19	Reference
12	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
28	Substrates and Products (Substrate)
8	Subunits
37	Synonyms
1	Systematic Name

Engineering

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Engineering on EC 1.14.18.9 - 4alpha-methylsterol monooxygenase

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Go to Protein Variants Search

H173Q

2 entries

Y244C

2 entries

N48D/V133A/F135S

Saccharomyces cerevisiae

construction of diverse mutants by random mutagenesis, isolation of the temperature-sensitive mutant strain mERG25 which grows normally at 28°C, but fails to grow at 38°C showing an altered sterol profile

658997

additional information

3 entries