1.14.18.9: 4alpha-methylsterol monooxygenase
This is an abbreviated version!
For detailed information about 4alpha-methylsterol monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.9
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1.14.18.9
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ergosterol
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lanosterol
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4,4-dimethylzymosterol
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erg27p
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psoriasiform
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smith-lemli-opitz
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meiosis-activating
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methylsterols
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medicine
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agriculture
- 1.14.18.9
- ergosterol
- lanosterol
- 4,4-dimethylzymosterol
- erg27p
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psoriasiform
-
smith-lemli-opitz
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meiosis-activating
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methylsterols
- medicine
- agriculture
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
4,4-dimethyl-sterol 4alpha-methyl-oxidase, 4,4-dimethyl-zymosterol 4alpha-methyl-oxidase, 4-methyl sterol oxidase, 4-methylsterol oxidase, C-4 methyl sterol oxidase, C-4 sterol methyl oxidase, EC 1.14.13.72, EC 1.14.99.16, ERG25, ERG25p, GintSMO protein, methyl sterol oxidase, methylsterol hydroxylase, methylsterol monooxygenase, NAD(P)H-dependent methylsterol oxidase, SC4MOL, SMO, sterol C-4 methyloxidase, sterol C4 methyl oxidase, sterol-C4-methyl oxidase, sterol-C4-methyl-oxidase
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Natural Substrates Products
Natural Substrates Products on EC 1.14.18.9 - 4alpha-methylsterol monooxygenase
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REACTION DIAGRAM
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + a ferricytochrome + H2O
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + H2O
4,4-dimethyl-zymosterol + reduced acceptor + O2
4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
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a step in the ergosterol biosynthesis, pathway, overview
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4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferricytochrome + H2O
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + a ferricytochrome + H2O
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step 3 of 3 of the overall reaction
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3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + a ferricytochrome + H2O
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step 3 of 3 of the overall reaction
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4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + H2O
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step 1 of 3 of the overall reaction
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?
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferricytochrome + H2O
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step 1 of 3 of the overall reaction
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?
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferricytochrome + H2O
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step 2 of 3 of the overall reaction
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?
4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + a ferrocytochrome + O2
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + a ferricytochrome + H2O
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step 2 of 3 of the overall reaction
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the enzyme is involved in cholesterol biosynthesis, (24S)-hydroxycholesterol downregulates cholesterol synthesis in neurons, possibly, in a posttranscriptional manner through SREBP-2, overview
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additional information
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squalene is sterol precursor, 24-methyl and 24-ethyl cholesterol are major sterol compounds in arbuscular mycorrhizal fungi, biosynthetic intermediates are lanosterol and 24-methylene lanosterol
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additional information
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squalene is sterol precursor, 24-methyl and 24-ethyl cholesterol are major sterol compounds in arbuscular mycorrhizal fungi, biosynthetic intermediates are lanosterol and 24-methylene lanosterol
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additional information
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enzyme is a key enzyme in ergosterol biosynthetic pathway in fungi, determination and analysis of sterol content in wild-type and mutant strains
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additional information
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enzyme plays a key role in sterol biosynthesis as component of the sterol-4-demethylation multienzyme complex, sterol metabolites analysis, overview
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additional information
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enzyme plays a key role in sterol biosynthesis as component of the sterol-4-demethylation multienzyme complex, sterol metabolites analysis, overview
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