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1.14.18.9: 4alpha-methylsterol monooxygenase

This is an abbreviated version!
For detailed information about 4alpha-methylsterol monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.9

Reaction

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate
 + 2 ferricytochrome b5 +
H2O

Synonyms

4,4-dimethyl-sterol 4alpha-methyl-oxidase, 4,4-dimethyl-zymosterol 4alpha-methyl-oxidase, 4-methyl sterol oxidase, 4-methylsterol oxidase, C-4 methyl sterol oxidase, C-4 sterol methyl oxidase, EC 1.14.13.72, EC 1.14.99.16, ERG25, ERG25p, GintSMO protein, methyl sterol oxidase, methylsterol hydroxylase, methylsterol monooxygenase, NAD(P)H-dependent methylsterol oxidase, SC4MOL, SMO, sterol C-4 methyloxidase, sterol C4 methyl oxidase, sterol-C4-methyl oxidase, sterol-C4-methyl-oxidase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.9 4alpha-methylsterol monooxygenase

Inhibitors

Inhibitors on EC 1.14.18.9 - 4alpha-methylsterol monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4alpha-(cyanomethyl)-5alpha-cholestan-3beta-ol
-
competitive inhibitor
6-amino-2-n-pentylbenzothiazole
-
-
cytochrome c
-
-
fenhexamid
fungicide, sterol biosynthesis inhibitor, 9.3 mg/l growth medium (long term exposure for 8 weeks) inhibits germ tube length by 50%, no change in enzyme transcription (0.2-2 mg/l growth medium)
fenpropimorph
fungicide, sterol biosynthesis inhibitor, 6.4 mg/l growth medium (long term exposure for 8 weeks) inhibits germ tube length by 50%, strong decrease in transcription levels with 2 mg/l growth medium, 10 mg/l decreases the fraction of vital stained fungal cells (after 2 and 7 days of treatment), leads to a increase in enzyme mRNA, does not change relative sterol composition and sterol amounts but reduced squalen content by 87% after 7 days of treatment
Trypsin
-
30 min treatment, 18% of original concentration of cytochrome b5 left
-
additional information
-
(24S)-hydroxycholesterol downregulates the expression of several members of the cholesterol/isoprenoid synthesis pathways including the methylsterol monooxygenase, overview
-