2.4.1.255: protein O-GlcNAc transferase
This is an abbreviated version!
For detailed information about protein O-GlcNAc transferase, go to the full flat file.
Word Map on EC 2.4.1.255
Reaction
Synonyms
beta-N-acetylglucosaminidase, EGF domain-specific O-GlcNAc transferase, EGF domain-specific O-linked N-acetylglucosamine transferase, EOGT, EOGT1, epidermal growth factor domain-specific O-GlcNAc transferase, glycosyltransferase OGT, Gtf1, GtfA, hOGT, HsOGT, human OGT, mammalian OGT, mOGT, More, N-acetylglucosamine transferase, N-acetylglucosamine-peptide N-acetylglucosaminyltransferase, N-acetylglucosaminyltransferase, ncOGT, nuclear cytoplasmic OGT, nucleocytoplasmic glycosyltransferase, nucleocytoplasmic OGT, O-GlcNAc protein, O-GlcNAc transferase, O-GlcNAc transferase OGT, O-GlcNAc-transferase, O-GlcNAcase, O-glycosylated protein p135, O-linked beta-N-acetylglucosamine transferase, O-linked beta-N-acetylglucosaminyltransferase, O-linked GlcNAc transferase, O-linked N-acetylglucosamine transferase, O-linked N-acetylglucosaminyltransferase, O-N-acetylglucosamine (O-GlcNAc) transferase, OGT, OGT p110, OGT protein, ogta, OGTase, OGTase protein, ogtb, p135, Protein SECRET AGENT, SEC, SECRET AGENT, sOGT, spindly, SPY, super sex combs, Sxc, Synpcc7942_0051, transferase OGT, UDP-GlcNAc: polypeptide O-N-acetylglucosaminyltransferase, UDP-GlcNAc:polypeptidyl transferase, UDP-N-acetylglucosaminyl transferase, uridine diphosphate-N-acetyl-D-glucosamine:polypeptidyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase, XcOGT, XcOGT protein
ECTree
2.4.1.255 protein O-GlcNAc transferaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 2.4.1.255 - protein O-GlcNAc transferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-serine
UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
octamer-binding protein 4 (Oct4) is one of the key transcription factors required for pluripotency of embryonic stem cell and more recently, the generation of induced pluripotent stem cells. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. Human Oct4 activity is regulated by O-linked N-acetylglucosamine transferase by a mechanism that is distinct from mouse Oct4
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + [octamer-binding protein 4]-L-threonine
UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
octamer-binding protein 4 (Oct4) is one of the key transcription factors required for pluripotency of embryonic stem cell and more recently, the generation of induced pluripotent stem cells. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. The action of Oct4 is modulated by the addition of several post-translational modifications, including O-GlcNAc. Human Oct4 activity is regulated by O-linked N-acetylglucosamine transferase by a mechanism that is distinct from mouse Oct4
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine
UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine
UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions
-
-
?
additional information
?
-
catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to Ser/Thr residues of proteins
-
-
?
additional information
?
-
-
catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to Ser/Thr residues of proteins
-
-
?
additional information
?
-
-
enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues. In the plant Arabidopsis, OGT serves to attenuate the gibberillin pathway
-
-
?
additional information
?
-
enzyme modifies the Plum pox virus capsid protein
-
-
?
additional information
?
-
enzyme modifies the Plum pox virus capsid protein
-
-
?
additional information
?
-
-
enzyme modifies the Plum pox virus capsid protein
-
-
?
additional information
?
-
participates in plum pox virus infection, plants are inoculated with PPV-NK-GFP and observed at different times postinoculation under a fluorescence microscope
-
-
?
additional information
?
-
participates in plum pox virus infection, plants are inoculated with PPV-NK-GFP and observed at different times postinoculation under a fluorescence microscope
-
-
?
additional information
?
-
-
participates in plum pox virus infection, plants are inoculated with PPV-NK-GFP and observed at different times postinoculation under a fluorescence microscope
-
-
?
additional information
?
-
-
catalyzes the transfer of O-linked GlcNAc to serine or threonine residues of a variety of substrate proteins, including nuclear pore proteins, transcription factors, and proteins implicated in diabetes and neurodegenerative disorders
-
-
?
additional information
?
-
-
catalyzes the transfer of O-linked GlcNAc to serine/threonine residues of a variety of target proteins, many of which have been implicated in such diseases as diabetes and neurodegeneration
-
-
?
additional information
?
-
-
enzyme transfers N-acetylglucosamine from UDP-GlcNAc to selected serine and threonine residues
-
-
?
additional information
?
-
-
regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1
-
-
?
additional information
?
-
-
regulation of O-GlcN acylation over a broad range of glucose concentrations, significant induction of O-GlcNAc modification of a limited number of proteins under conditions of glucose deprivation
-
-
?
additional information
?
-
-
transfer of O-linked GlcNAc to serine/threonine residues of a variety of substrate proteins, including nuclear pore proteins, transcription factors, and proteins implicated in diabetes and neurodegenerative disorders
-
-
?
additional information
?
-
-
enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues. Substrates are many proteins, e.g. transcription factors, kinases, cytoskeletal proteins, and nuclear pore proteins
-
-
?
additional information
?
-
-
enzyme catalyzes the addition of O-GlcNAc moieties to nuclear and cytoplasmic proteins at serine and threonine residues, regulates some aspects of mitotic chromatin dynamics. OGT protein amounts decrease during M phase
-
-
?
additional information
?
-
-
enzyme is a key molecule for the timely progression of the cell cycle. Microinject recombinant proteins into oocytes to detail the relationship between cell cycle and O-GlcNAc
-
-
?
additional information
?
-
-
enzyme modifies nuclear pore proteins and transcription factors
-
-
?
additional information
?
-
-
enzyme transfers GlcNAc onto substrate proteins using UDP-GlcNAc as the sugar donor
-
-
?
additional information
?
-
-
enzyme catalyzes the addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases
-
-
?
additional information
?
-
-
participates in plum pox virus infection, plants are inoculated with plum pox virus-NK-GFP and observed at different times postinoculation under a fluorescence microscope
-
-
?
additional information
?
-
catalyses the O-linked attachment of single GlcNAc moieties to serine and threonine residues on many cytosolic or nuclear proteins
-
-
?
additional information
?
-
catalyzes the attachment of GlcNAc monosaccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway
-
-
?
additional information
?
-
-
enzyme catalyzes the abundant and dynamic posttranslational modification of nuclear and cytosolic proteins by beta-O-linked N-acetylglucosamine (O-GlcNAc)
-
-
?
additional information
?
-
-
O-GlcNAc transferase, the enzyme that adds O-GlcNAc to proteins, exists in stable and active complexes with the serine/threonine phosphatases PP1beta and PP1gamma, enzymes that remove phosphate from proteins
-
-
?
additional information
?
-
-
p110 subunit of the enzyme forms both homo- and heterotrimers that appear to have different binding affinities for UDP-GlcNAc
-
-
?
additional information
?
-
-
enzyme adds a single GlcNAc to hydroxyl groups of serine and threonine residues
-
-
?
additional information
?
-
-
enzyme transfers GlcNAc onto substrate proteins using UDP-GlcNAc as the sugar donor
-
-
?
