2.4.1.255: protein O-GlcNAc transferase This is an abbreviated version! For detailed information about protein O-GlcNAc transferase, go to the full flat file .
Word Map on EC 2.4.1.255
Reaction
UDP-N-acetyl-alpha-D-glucosamine +
[protein]-L-serine =
UDP +
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
Synonyms beta-N-acetylglucosaminidase, EGF domain-specific O-GlcNAc transferase, EGF domain-specific O-linked N-acetylglucosamine transferase, EOGT, EOGT1, epidermal growth factor domain-specific O-GlcNAc transferase, glycosyltransferase OGT, Gtf1, GtfA, hOGT, HsOGT, human OGT, mammalian OGT, mOGT, More, N-acetylglucosamine transferase, N-acetylglucosamine-peptide N-acetylglucosaminyltransferase, N-acetylglucosaminyltransferase, ncOGT, nuclear cytoplasmic OGT, nucleocytoplasmic glycosyltransferase, nucleocytoplasmic OGT, O-GlcNAc protein, O-GlcNAc transferase, O-GlcNAc transferase OGT, O-GlcNAc-transferase, O-GlcNAcase, O-glycosylated protein p135, O-linked beta-N-acetylglucosamine transferase, O-linked beta-N-acetylglucosaminyltransferase, O-linked GlcNAc transferase, O-linked N-acetylglucosamine transferase, O-linked N-acetylglucosaminyltransferase, O-N-acetylglucosamine (O-GlcNAc) transferase, OGT, OGT p110, OGT protein, ogta, OGTase, OGTase protein, ogtb, p135, Protein SECRET AGENT, SEC, SECRET AGENT, sOGT, spindly, SPY, super sex combs, Sxc, Synpcc7942_0051, transferase OGT, UDP-GlcNAc: polypeptide O-N-acetylglucosaminyltransferase, UDP-GlcNAc:polypeptidyl transferase, UDP-N-acetylglucosaminyl transferase, uridine diphosphate-N-acetyl-D-glucosamine:polypeptidyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase, XcOGT, XcOGT protein
ECTree
Localization
Localization on EC 2.4.1.255 - protein O-GlcNAc transferase
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additional information
immunoelectron microscopy shows that OGT is localized to the euchromatin of the nucleus and around the secretory granules of exocrine acinar cells and endocrine islet cells
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mostly localized
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the enzyme exists in the nucleus and cytosol simultaneously
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unlike previously described glycosyltransferases, OGT is localized to the cytosol and nucleus
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mitochondrial and nuclear/cytoplasmic variants of OGT
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isoform 2
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mitochondrial and nuclear/cytoplasmic variants of OGT
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isoforms 3 and 4
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amino acids residues 451-453 (DFP) are characterised as the nuclear localisation signal of the enzyme. Tne enzyme binds the importin alpha5 protein, and this association is abolished when the DFP motif of the enzyme is mutated or deleted. O-GlcNAcylation of Ser389, which resides in the tetratricopeptide repeats, plays an important role in the nuclear localisation of the enzyme
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unlike previously described glycosyltransferases, OGT is localized to the cytosol and nucleus
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