Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | O-linked N-acetylglucosamine transferase is encoded by a single gene that yields nucleocytosolic and mitochondrial isoforms | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
mOGT | - |
Homo sapiens |
O-GlcNAc transferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | reducing endogenous mOGT expression leads to alterations in mitochondrial structure and function, including Drp1-dependent mitochondrial fragmentation, reduction in mitochondrial membrane potential, and a significant loss of mitochondrial content in the absence of mitochondrial ROS | Homo sapiens |
physiological function | mitochondrial O-GlcNAc transferase regulates mitochondrial structure, function, and survival in HeLa cell | Homo sapiens |