2.3.1.257: N-terminal L-serine Nalpha-acetyltransferase NatD

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For detailed information about N-terminal L-serine Nalpha-acetyltransferase NatD, go to the full flat file.

Reaction

Synonyms

EC 2.3.1.88, hNAA40, hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-acetyltransferase 11, N-alpha-acetyltransferase 40, Naa40, Naa40p, Nat11, NAT4, NatD, Patt1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.257 N-terminal L-serine Nalpha-acetyltransferase NatD

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Results	in table
2840	AA Sequence
1	Application
5	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
50	Disease/ Diagnostics
3	Expression
6	General Information
6	Localization
22	Natural Substrates/ Products (Substrates)
10	Organism
4	PDB ID
1	pH Optimum
10	Protein Variants
5	Purification (Commentary)
2	Reaction
9	Reference
13	Source Tissue
30	Substrates and Products (Substrate)
31	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD

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SYSTEMATIC NAME

IUBMB Comments

acetyl-CoA:N-terminal-L-seryl-[histone 4/2A] L-serine Nalpha-acetyltransferase

N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus.