2.3.1.257: N-terminal L-serine Nalpha-acetyltransferase NatD

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For detailed information about N-terminal L-serine Nalpha-acetyltransferase NatD, go to the full flat file.

Reaction

Synonyms

EC 2.3.1.88, hNAA40, hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-acetyltransferase 11, N-alpha-acetyltransferase 40, Naa40, Naa40p, Nat11, NAT4, NatD, Patt1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.257 N-terminal L-serine Nalpha-acetyltransferase NatD

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Results	in table
2840	AA Sequence
1	Application
5	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
50	Disease/ Diagnostics
3	Expression
6	General Information
6	Localization
22	Natural Substrates/ Products (Substrates)
10	Organism
4	PDB ID
1	pH Optimum
10	Protein Variants
5	Purification (Commentary)
2	Reaction
9	Reference
13	Source Tissue
30	Substrates and Products (Substrate)
31	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Disease

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Disease on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinoma, Hepatocellular

Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells.

19695338

Colonic Neoplasms

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.

26666750

Colonic Neoplasms

NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.

30858358

Colorectal Neoplasms

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.

26666750

Colorectal Neoplasms

NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.

30858358

Diabetes Mellitus

Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.

31920356

Diabetes Mellitus, Type 2

Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.

31920356

Liver Neoplasms

Identification of NAA40 as a Potential Prognostic Marker for Aggressive Liver Cancer Subtypes.

34150665

Liver Neoplasms

N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.

32942614

n-terminal l-serine nalpha-acetyltransferase natd deficiency

Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis.

22231784

Neoplasms

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.

26666750

Neoplasms

Identification of NAA40 as a Potential Prognostic Marker for Aggressive Liver Cancer Subtypes.

34150665

Neoplasms

N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.

32942614

Neoplasms

NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.

30858358

Obesity

Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.

31920356

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