2.3.1.257: N-terminal L-serine Nalpha-acetyltransferase NatD

This is an abbreviated version!
For detailed information about N-terminal L-serine Nalpha-acetyltransferase NatD, go to the full flat file.

Reaction

Synonyms

EC 2.3.1.88, hNAA40, hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-acetyltransferase 11, N-alpha-acetyltransferase 40, Naa40, Naa40p, Nat11, NAT4, NatD, Patt1

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.257 N-terminal L-serine Nalpha-acetyltransferase NatD

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Results	in table
2840	AA Sequence
1	Application
5	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
50	Disease/ Diagnostics
3	Expression
6	General Information
6	Localization
22	Natural Substrates/ Products (Substrates)
10	Organism
4	PDB ID
1	pH Optimum
10	Protein Variants
5	Purification (Commentary)
2	Reaction
9	Reference
13	Source Tissue
30	Substrates and Products (Substrate)
31	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

acetyl-CoA + an N-terminal-L-seryl-[histone H2A]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA

4 entries

acetyl-CoA + an N-terminal-L-seryl-[histone H4]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

5 entries

acetyl-CoA + N-terminal-L-seryl1-[histone H2A]

N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA

2 entries

acetyl-CoA + N-terminal-L-seryl1-[histone H4]

N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA

2 entries

acetyl-CoA + peptide

CoA + Nalpha-acetylpeptide

Homo sapiens

Q86UY6

hNaa40p preferentially acetylates Ser-Gly-Gly-Gly-Lys- starting peptides

720835

-

-

?

acetyl-CoA + Ser-Gly-Arg-Gly

acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys

2 entries

acetyl-CoA + Ser-Gly-Gly-Lys

acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys

2 entries

additional information

?

-

2 entries

acetyl-CoA + an N-terminal-L-seryl-[histone H2A]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA

Homo sapiens

Q86UY6

-

720835

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H2A]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA

Homo sapiens

Q86UY6

-

735456, 741447

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H2A]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA

Saccharomyces cerevisiae

-

-

659258, 740992

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H2A]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA

Saccharomyces cerevisiae B-15329

-

-

740992

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H4]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

Homo sapiens

Q86UY6

-

720835

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H4]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

Homo sapiens

Q86UY6

-

735456, 741447

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H4]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

Saccharomyces cerevisiae

-

-

659258

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H4]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

Saccharomyces cerevisiae

-

efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4

740992

-

-

?

acetyl-CoA + an N-terminal-L-seryl-[histone H4]

an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

Saccharomyces cerevisiae B-15329

-

efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4

740992

-

-

?

acetyl-CoA + N-terminal-L-seryl1-[histone H2A]

N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA

Homo sapiens

Q86UY6

-

756385, 756553

-

-

?

acetyl-CoA + N-terminal-L-seryl1-[histone H2A]

N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA

Homo sapiens

-

-

756553

-

-

?

acetyl-CoA + N-terminal-L-seryl1-[histone H4]

N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA

Homo sapiens

Q86UY6

-

756385, 756553

-

-

?

acetyl-CoA + N-terminal-L-seryl1-[histone H4]

N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA

Homo sapiens

-

-

756553

-

-

?

acetyl-CoA + Ser-Gly-Arg-Gly

acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys

Saccharomyces cerevisiae

-

-

740992

-

-

?

acetyl-CoA + Ser-Gly-Arg-Gly

acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys

Saccharomyces cerevisiae B-15329

-

-

740992

-

-

?

acetyl-CoA + Ser-Gly-Gly-Lys

acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys

Saccharomyces cerevisiae

-

-

740992

-

-

?

acetyl-CoA + Ser-Gly-Gly-Lys

acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys

Saccharomyces cerevisiae B-15329

-

-

740992

-

-

?

additional information

?

-

Homo sapiens

Q86UY6

hNaa40p is a NAT selectively acetylating Ser-Gly or Gly-Gly starting peptides. NatD also is defined as the catalytic unit Naa40p (Nat4) which co-translationally Nt-acetylates histones H2A and H4. Recombinant hNaa40p Nt-acetylates the oligopeptides derived from the N-termini of both histones

720835

-

-

?

additional information

?

-

Homo sapiens

-

hNaa40p is a NAT selectively acetylating Ser-Gly or Gly-Gly starting peptides. NatD also is defined as the catalytic unit Naa40p (Nat4) which co-translationally Nt-acetylates histones H2A and H4. Recombinant hNaa40p Nt-acetylates the oligopeptides derived from the N-termini of both histones

720835

-

-

?