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2.3.1.257: N-terminal L-serine Nalpha-acetyltransferase NatD

This is an abbreviated version!
For detailed information about N-terminal L-serine Nalpha-acetyltransferase NatD, go to the full flat file.

Reaction

acetyl-CoA
+
an N-terminal-L-seryl-[histone H2A]
=
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A]
 +
CoA

Synonyms

EC 2.3.1.88, hNAA40, hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-acetyltransferase 11, N-alpha-acetyltransferase 40, Naa40, Naa40p, Nat11, NAT4, NatD, Patt1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.257 N-terminal L-serine Nalpha-acetyltransferase NatD

Engineering

Engineering on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D127A/E129A
the mutant shows significantly decreased catalytic efficiency (1.6-18fold) compared to the wild type enzyme
E139Q
inactive
T174A
the mutant shows wild type catalytic efficiency
W90A
the mutant exhibits markedly decreased catalytic efficiency (2.8fold) compared to the wild type enzyme
Y136A
the mutant shows significantly decreased catalytic efficiency (1.6-1.8fold) compared to the wild type enzyme
Y136F
the catalytic efficiency of the mutant is modestly affected compared to the wild type enzyme
Y138A
the mutant shows significantly decreased catalytic efficiency (1.6-1.8fold) compared to the wild type enzyme
Y211A
the mutant shows wild type catalytic efficiency
Y85A
the mutant exhibits markedly decreased catalytic efficiency (5.8fold) compared to the wild type enzyme
additional information