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2.3.1.257: N-terminal L-serine Nalpha-acetyltransferase NatD

This is an abbreviated version!
For detailed information about N-terminal L-serine Nalpha-acetyltransferase NatD, go to the full flat file.

Reaction

acetyl-CoA
+
an N-terminal-L-seryl-[histone H2A]
=
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A]
 +
CoA

Synonyms

EC 2.3.1.88, hNAA40, hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-acetyltransferase 11, N-alpha-acetyltransferase 40, Naa40, Naa40p, Nat11, NAT4, NatD, Patt1

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.257 N-terminal L-serine Nalpha-acetyltransferase NatD

Expression

Expression on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
glucose intake results in a significant increase in expression of hNAA40 at 1 h and a significant decrease at 3 h post intake
increase in hNAA40 and a decrease in NAMPT and SIRT-1 expression in PBMC from drugnaive obese type 2 diabetes mellitus (T2DM) persons. Metformin treatment reverts hNAA40, NAMPT, and SIRT-1 expression levels to normal levels. Glucose intake results in a significant increase in expression of hNAA40 at 1 h and a significant decrease at 3 h post intake. Lipid intake results in an increase in expression of hNAA40 at 2 h post intake and a return to normal levels at 3 h
NAA40 is significantly upregulated in primary colorectal cancer (CRC) tissues and promotes CRC cell growth both in vitro and in xenograft tumor models