2.3.1.257: N-terminal L-serine Nalpha-acetyltransferase NatD
This is an abbreviated version!
For detailed information about N-terminal L-serine Nalpha-acetyltransferase NatD, go to the full flat file.
Reaction
Synonyms
EC 2.3.1.88, hNAA40, hNaa40p/hNatD, N(alpha)-acetyltransferase 40, N-acetyltransferase 11, N-alpha-acetyltransferase 40, Naa40, Naa40p, Nat11, NAT4, NatD, Patt1
ECTree
2.3.1.257 N-terminal L-serine Nalpha-acetyltransferase NatDAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
acetyl-CoA + histone H2A
CoA + Nalpha-acetyl-histone H2A
Saccharomyces cerevisiae histone H2A, 2SGGKGGKAGSAAKASQSR19 N-terminal sequence
-
-
?
acetyl-CoA + histone H4
CoA + Nalpha-acetyl-histone H4
Saccharomyces cerevisiae histone H4, 2SGRGKGGKGLGKGGAKR18 N-terminal sequence. hNaa40p catalyzes H4 Nalpha-acetylation and not H4 lysine Nepsilon-acetylation, immunoprecipitated hNaa40p specifically Nt-acetylates H4 in vitro
-
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H2A]
N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA
acetyl-CoA + N-terminal-L-seryl1-[histone H4]
N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
-
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4
-
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4
-
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H2A]
N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA
-
-
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H2A]
N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA
-
-
-
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H4]
N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA
-
-
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H4]
N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA
-
-
-
-
?
acetyl-CoA + peptide
CoA + Nalpha-acetylpeptide
hNaa40p preferentially acetylates Ser-Gly-Gly-Gly-Lys- starting peptides
-
-
?
acetyl-CoA + Ser-Gly-Arg-Gly
acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys
-
-
-
-
?
acetyl-CoA + Ser-Gly-Arg-Gly
acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys
-
-
-
-
?
acetyl-CoA + Ser-Gly-Gly-Lys
acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys
-
-
-
-
?
acetyl-CoA + Ser-Gly-Gly-Lys
acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys
-
-
-
-
?
additional information
?
-
hNaa40p is a NAT selectively acetylating Ser-Gly or Gly-Gly starting peptides. NatD also is defined as the catalytic unit Naa40p (Nat4) which co-translationally Nt-acetylates histones H2A and H4. Recombinant hNaa40p Nt-acetylates the oligopeptides derived from the N-termini of both histones
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-
?
additional information
?
-
-
hNaa40p is a NAT selectively acetylating Ser-Gly or Gly-Gly starting peptides. NatD also is defined as the catalytic unit Naa40p (Nat4) which co-translationally Nt-acetylates histones H2A and H4. Recombinant hNaa40p Nt-acetylates the oligopeptides derived from the N-termini of both histones
-
-
?
additional information
?
-
specificity determination using an in vitro proteome-derived peptide library Nt-acetylation assay, in vitro acetylation using synthetic oligopeptides as substrates, overview
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-
?
additional information
?
-
-
specificity determination using an in vitro proteome-derived peptide library Nt-acetylation assay, in vitro acetylation using synthetic oligopeptides as substrates, overview
-
-
?
additional information
?
-
the enzyme does not catalyze H4 lysine Nepsilon-acetylation
-
-
?
additional information
?
-
-
the enzyme does not catalyze H4 lysine Nepsilon-acetylation
-
-
?
additional information
?
-
-
does not acetylate histone H3 or adrenocorticotropin
-
-
?
additional information
?
-
-
the enzyme does not acetylate histone H3, adrenocorticotropin, and an altered iso-1-cytochrome c protein with short NatD type N termini (SGGKGGKA)
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-
?
additional information
?
-
-
the enzyme does not acetylate histone H3, adrenocorticotropin, and an altered iso-1-cytochrome c protein with short NatD type N termini (SGGKGGKA)
-
-
?
