1.14.20.6: flavonol synthase
This is an abbreviated version!
For detailed information about flavonol synthase, go to the full flat file.
Word Map on EC 1.14.20.6
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1.14.20.6
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flavonols
-
flavanone
-
chalcone
-
dihydroflavonols
-
kaempferol
-
anthocyanidins
-
4-reductase
-
dihydrokaempferol
-
3\'-hydroxylase
-
leucoanthocyanidin
-
r2r3-myb
-
dihydroquercetin
-
3beta-hydroxylase
-
fagopyrum
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tataricum
-
2-odds
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2s-naringenin
-
dihydroflavonol-4-reductase
-
unshius
-
analysis
-
synthesis
-
tartary
-
flavonol-specific
- 1.14.20.6
- flavonols
- flavanone
- chalcone
- dihydroflavonols
- kaempferol
- anthocyanidins
-
4-reductase
- dihydrokaempferol
-
3\'-hydroxylase
-
leucoanthocyanidin
-
r2r3-myb
- dihydroquercetin
-
3beta-hydroxylase
- fagopyrum
- tataricum
- 2-odds
- 2s-naringenin
- dihydroflavonol-4-reductase
- unshius
- analysis
- synthesis
-
tartary
-
flavonol-specific
Reaction
Synonyms
AaFLS1, BnFLS, Cs-COR054, Cs-COR113, EC 1.14.11.23, FKS2, flavonoid 2-oxoglutarate-dependent dioxygenase, flavonol synthase, FLS, FLS1, FLS2, fls3, McFLS, NtFLS1, PhFLS, PpFLS, RrFLS1, SbFLS, VcFLS
ECTree
1.14.20.6 flavonol synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.14.20.6 - flavonol synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(+)-trans-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
(2R)-naringenin + 2-oxoglutarate + O2
(-)-trans-dihydrokaempferol + succinate + CO2 + H2O
-
-
-
-
?
(2R)-naringenin + 2-oxoglutarate + O2
(2S,3R)-dihydrokaempferol + succinate + CO2 + H2O
-
transhydroxylation
-
-
?
(2R)-naringenin + 2-oxoglutarate + O2
(2S,3S)-dihydrokaempferol + succinate + CO2 + H2O
-
-
+ low amounts of kaempferol
-
?
(2R)-naringenin + 2-oxoglutarate + O2
? + succinate + CO2 + H2O
-
-
-
-
?
(2R,3R)-trans-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
?
(2R,3S,4R)-trans-leucocyanidin + 2-oxoglutarate + O2
? + succinate + CO2 + H2O
-
-
-
-
?
(2S)-naringenin + 2-oxoglutarate + O2
(2R,3S)-cis-dihydrokaempferol + (2R,3R)-trans-dihydrokaempferol + apigenin + kaempferol + succinate + CO2 + H2O
(2S)-naringenin + 2-oxoglutarate + O2
(2R,3S)-dihydrokaempferol + (2S,3S)-dihydrokaempferol + kaempferol + succinate + CO2 + H2O
-
-
-
-
?
(2S)-naringenin + 2-oxoglutarate + O2
? + succinate + CO2 + H2O
-
-
-
-
?
(2S)-naringenin + 2-oxoglutarate + O2
dihydrokaempferol + kaempferol + succinate + CO2 + H2O
poor substrate
-
-
?
(2S)-naringenin + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
3'-O-methyltaxifolin + 2-oxoglutarate + O2
isorhamnetin + succinate + CO2 + H2O
-
-
-
?
a dihydroflavonol + 2-oxoglutarate + O2
a flavonol + succinate + CO2 + H2O
-
-
-
?
cis-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
weak reaction, only traces of kaempferol produced
-
-
?
pinobanksin + 2-oxoglutarate + O2
galangin + succinate + CO2 + H2O
-
-
-
?
trans-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
(2R/3R)-dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
(2R/3R)-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
(2R/3R)-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
?
(2R/3R)-dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
?
(2S)-naringenin + 2-oxoglutarate + O2
(2R,3S)-cis-dihydrokaempferol + (2R,3R)-trans-dihydrokaempferol + apigenin + kaempferol + succinate + CO2 + H2O
-
-
-
-
?
(2S)-naringenin + 2-oxoglutarate + O2
(2R,3S)-cis-dihydrokaempferol + (2R,3R)-trans-dihydrokaempferol + apigenin + kaempferol + succinate + CO2 + H2O
-
-
(2R,3S)-dihydrokaempferol is the predominant two-electron oxidation product
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
good substrate
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?, r
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
r
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
ir
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
the mutated enzymes L311F, Y240P, F146I, A120M and L311F-A120M are all able to oxidize dihydrokaempferol to kaempferol, with respective catalytic activities relative to the wild type level of 355%, 104%, 86%, 162% and 175%. L311F substitution increases the flavonol synthase activity
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
ir
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydrokaempferol + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
dihydromyricetin + 2-oxoglutarate + O2
myricetin + succinate + CO2 + H2O
-
-
-
?
dihydromyricetin + 2-oxoglutarate + O2
myricetin + succinate + CO2 + H2O
-
-
-
-
?
dihydromyricetin + 2-oxoglutarate + O2
myricetin + succinate + CO2 + H2O
-
-
-
?
dihydromyricetin + 2-oxoglutarate + O2
myricetin + succinate + CO2 + H2O
-
-
-
-
ir
dihydromyricetin + 2-oxoglutarate + O2
myricetin + succinate + CO2 + H2O
-
-
-
-
ir
dihydromyricetin + 2-oxoglutarate + O2
myricetin + succinate + CO2 + H2O
-
-
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
poor substrate
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
?, r
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
r
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
?
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
ir
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
ir
dihydroquercetin + 2-oxoglutarate + O2
quercetin + succinate + CO2 + H2O
-
-
-
-
?
naringenin + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
naringenin + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
-
?
naringenin + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
-
?
naringenin + 2-oxoglutarate + O2
kaempferol + succinate + CO2 + H2O
-
-
in a second reaction step with kaempferol 3-O-methyltransferase kaempferol is converted into 3-O-methylkaempferol
-
?
additional information
?
-
substrates are bound with similar affinity
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of flavonoids
-
-
?
additional information
?
-
flavonol synthase and flavanone 3beta-hydroxylase are key enzymes in the biosynthesis of the UV-B protectant, kaempferol
-
-
?
additional information
?
-
-
flavonol synthase and flavanone 3beta-hydroxylase are key enzymes in the biosynthesis of the UV-B protectant, kaempferol
-
-
?
