1.14.20.6: flavonol synthase
This is an abbreviated version!
For detailed information about flavonol synthase, go to the full flat file.
Word Map on EC 1.14.20.6
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1.14.20.6
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flavonols
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flavanone
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chalcone
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dihydroflavonols
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kaempferol
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anthocyanidins
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4-reductase
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dihydrokaempferol
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3\'-hydroxylase
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leucoanthocyanidin
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r2r3-myb
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dihydroquercetin
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3beta-hydroxylase
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fagopyrum
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tataricum
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2-odds
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2s-naringenin
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dihydroflavonol-4-reductase
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unshius
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analysis
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synthesis
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tartary
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flavonol-specific
- 1.14.20.6
- flavonols
- flavanone
- chalcone
- dihydroflavonols
- kaempferol
- anthocyanidins
-
4-reductase
- dihydrokaempferol
-
3\'-hydroxylase
-
leucoanthocyanidin
-
r2r3-myb
- dihydroquercetin
-
3beta-hydroxylase
- fagopyrum
- tataricum
- 2-odds
- 2s-naringenin
- dihydroflavonol-4-reductase
- unshius
- analysis
- synthesis
-
tartary
-
flavonol-specific
Reaction
Synonyms
AaFLS1, BnFLS, Cs-COR054, Cs-COR113, EC 1.14.11.23, FKS2, flavonoid 2-oxoglutarate-dependent dioxygenase, flavonol synthase, FLS, FLS1, FLS2, fls3, McFLS, NtFLS1, PhFLS, PpFLS, RrFLS1, SbFLS, VcFLS
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Reference on EC 1.14.20.6 - flavonol synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wellmann, F.; Lukacin, R.; Moriguchi, T.; Britsch, L.; Schiltz, E.; Matern, U.
Functional expression and mutational analysis of flavonol synthase from Citrus unshiu
Eur. J. Biochem.
269
4134-4142
2002
Citrus unshiu (Q9ZWQ9), Citrus unshiu
Martens, S.; Forkmann, G.; Britsch, L.; Wellmann, F.; Matern, U.; Lukacin, R.
Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley
FEBS Lett.
544
93-98
2003
Petroselinum crispum (Q7XZQ6), Petroselinum crispum
Turnbull, J.J.; Nakajima, J.; Welford, R.W.; Yamazaki, M.; Saito, K.; Schofield, C.J.
Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase
J. Biol. Chem.
279
1206-1216
2004
Arabidopsis thaliana
Moriguchi, T.; Kita, M.; Ogawa, K.; Tomono, Y.; Endo, T.; Omura, M.
Flavonol synthase gene expression during citrus fruit development
Physiol. Plant.
114
251-258
2002
Citrus unshiu, Citrus unshiu Marc.
Prescott, A.G.; Stamford, N.P.; Wheeler, G.; Firmin, J.L.
In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana
Phytochemistry
60
589-593
2002
Arabidopsis thaliana
Lukacin, R.; Wellmann, F.; Britsch, L.; Martens, S.; Matern, U.
Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase
Phytochemistry
62
287-292
2003
Citrus unshiu
Stich, K.; Eidenberger, T.; Wurst, F.; Forkmann, G.
Flavonol synthase activity and the regulation of flavonol and anthocyanin biosynthesis during flower development in Dianthus caryophyllus L. (carnation)
Z. Naturforsch. C
47
553-560
1992
Dianthus caryophyllus
-
Fujita, A.; Goto-Yamamoto, N.; Aramaki, I.; Hashizume, K.
Organ-specific transcription of putative flavonol synthase genes of grapevine and effects of plant hormones and shading on flavonol biosynthesis in grape berry skins
Biosci. Biotechnol. Biochem.
70
632-638
2006
Vitis vinifera
Leonard, E.; Yan, Y.; Koffas, M.A.
Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli
Metab. Eng.
8
172-181
2006
Arabidopsis thaliana
Halbwirth, H.; Fischer, T.C.; Schlangen, K.; Rademacher, W.; Schleifer, K.; Forkmann, G.; Stich, K.
Screening for inhibitors of 2-oxoglutarate-dependent dioxygenases: Flavanone 3?-hydroxylase and flavonol synthase
Plant Sci.
171
194-205
2006
Malus domestica, Pyrus communis
Kim, B.G.; Kim, J.H.; Kim, J.; Lee, C.; Ahn, J.H.
Accumulation of flavonols in response to ultraviolet-B irradiation in soybean is related to induction of flavanone 3-beta-hydroxylase and flavonol synthase
Mol. Cells
25
247-252
2008
Glycine max (Q0EDG6), Glycine max
Chua, C.S.; Biermann, D.; Goo, K.S.; Sim, T.S.
Elucidation of active site residues of Arabidopsis thaliana flavonol synthase provides a molecular platform for engineering flavonols
Phytochemistry
69
66-75
2008
Arabidopsis thaliana (Q96330), Arabidopsis thaliana
Takahashi, R.; Githiri, S.M.; Hatayama, K.; Dubouzet, E.G.; Shimada, N.; Aoki, T.; Ayabe, S.; Iwashina, T.; Toda, K.; Matsumura, H.
A single-base deletion in soybean flavonol synthase gene is associated with magenta flower color
Plant Mol. Biol.
63
125-135
2007
Glycine max (Q0EDG6), Glycine max
Owens, D.K.; Alerding, A.B.; Crosby, K.C.; Bandara, A.B.; Westwood, J.H.; Winkel, B.S.
Functional analysis of a predicted flavonol synthase gene family in Arabidopsis
Plant Physiol.
147
1046-1061
2008
Arabidopsis thaliana, Arabidopsis thaliana (Q96330)
Lin, G.Z.; Lian, Y.J.; Ryu, J.H.; Sung, M.K.; Park, J.S.; Park, H.J.; Park, B.K.; Shin, J.S.; Lee, M.S.; Cheon, C.I.
Expression and purification of His-tagged flavonol synthase of Camellia sinensis from Escherichia coli
Protein Expr. Purif.
55
287-292
2007
Camellia sinensis (A2TJG2), Camellia sinensis
Preuss, A.; Stracke, R.; Weisshaar, B.; Hillebrecht, A.; Matern, U.; Martens, S.
Arabidopsis thaliana expresses a second functional flavonol synthase
FEBS Lett.
583
1981-1986
2009
Arabidopsis thaliana
Wang, L.; Li, X.; Zhao, Q.; Jing, S.; Chen, S.; Yuan, H.
Identification of genes induced in response to low-temperature treatment in tea leaves
Plant Mol. Biol. Rep.
27
257-265
2009
Camellia sinensis
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Stracke, R.; De Vos, R.C.; Bartelniewoehner, L.; Ishihara, H.; Sagasser, M.; Martens, S.; Weisshaar, B.
Metabolomic and genetic analyses of flavonol synthesis in Arabidopsis thaliana support the in vivo involvement of leucoanthocyanidin dioxygenase
Planta
229
427-445
2009
Arabidopsis thaliana (B1GV57), Arabidopsis thaliana (B2GVM7), Arabidopsis thaliana (B7SFQ0), Arabidopsis thaliana (Q96330), Arabidopsis thaliana (Q9FFQ5), Arabidopsis thaliana
Nakatsuka, A.; Mizuta, D.; Kii, Y.; Miyajima, I.; Kobayashi, N.
Isolation and expression analysis of flavonoid biosynthesis genes in evergreen azalea
Sci. Hortic.
118
314-320
2008
Rhododendron x pulchrum (A9ZMJ8)
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Ferreyra, M.L.; Rius, S.; Emiliani, J.; Pourcel, L.; Feller, A.; Morohashi, K.; Casati, P.; Grotewold, E.
Cloning and characterization of a UV-B-inducible maize flavonol synthase
Plant J.
62
77-91
2010
Zea mays
Kim, B.; Joe, E.; Ahn, J.
Molecular characterization of flavonol synthase from poplar and its application to the synthesis of 3-O-methylkaempferol
Biotechnol. Lett.
32
579-584
2010
Populus deltoides
Fang, F.; Tang, K.; Huang, W.
Changes of flavonol synthase and flavonol contents during grape berry development
Eur. Food Res. Technol.
237
529-540
2013
Vitis vinifera
Li, C.; Bai, Y.; Li, S.; Chen, H.; Han, X.; Zhao, H.; Shao, J.; Park, S.U.; Wu, Q.
Cloning, characterization, and activity analysis of a flavonol synthase gene FtFLS1 and its association with flavonoid content in tartary buckwheat
J. Agric. Food Chem.
60
5161-5168
2012
Fagopyrum tataricum (F5BR59), Fagopyrum tataricum
Li, X.; Kim, Y.B.; Kim, Y.; Zhao, S.; Kim, H.H.; Chung, E.; Lee, J.H.; Park, S.U.
Differential stress-response expression of two flavonol synthase genes and accumulation of flavonols in tartary buckwheat
J. Plant Physiol.
170
1630-1636
2013
Fagopyrum tataricum (F5BR59), Fagopyrum tataricum (M1GL48)
Xu, F.; Li, L.; Zhang, W.; Cheng, H.; Sun, N.; Cheng, S.; Wang, Y.
Isolation, characterization, and function analysis of a flavonol synthase gene from Ginkgo biloba
Mol. Biol. Rep.
39
2285-2296
2012
Ginkgo biloba (D0UZK7), Ginkgo biloba
Mahajan, M.; Joshi, R.; Gulati, A.; Yadav, S.
Increase in flavan-3-ols by silencing flavonol synthase mRNA affects the transcript expression and activity levels of antioxidant enzymes in tobacco
Plant Biol.
14
725-733
2012
Nicotiana tabacum (A9ZMJ0), Nicotiana tabacum (Q1PHN5), Nicotiana tabacum
Mahajan, M.; Ahuja, P.S.; Yadav, S.K.
Post-transcriptional silencing of flavonol synthase mRNA in tobacco leads to fruits with arrested seed set
PLoS ONE
6
e28315
2011
Nicotiana tabacum (A9ZMJ0), Nicotiana tabacum (Q1PHN5), Nicotiana tabacum
Toh, H.; Wang, S.; Chang, S.; Chu, F.
Molecular cloning and characterization of flavonol synthase in Acacia confusa
Tree Genet. Genomes
9
85-92
2013
Acacia confusa (H6V8U4)
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Han, X.J.; Wu, Y.F.; Gao, S.; Yu, H.N.; Xu, R.X.; Lou, H.X.; Cheng, A.X.
Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity
FEBS Lett.
588
2307-2314
2014
Plagiochasma appendiculatum (A0A076U8J8), Plagiochasma appendiculatum
Flores, G.; de la Pena Moreno, F.; Blanch, G.P.; del Castillo, M.L.
Phenylalanine ammonia-lyase, flavanone 3beta-hydroxylase and flavonol synthase enzyme activity by a new in vitro assay method in berry fruits
Food Chem.
153
130-133
2014
Rubus plicatus, Rubus idaeus, Ribes nigrum, Ribes rubrum, Fragaria x ananassa (Q07DT9), Fragaria x ananassa
Luo, P.; Ning, G.; Wang, Z.; Shen, Y.; Jin, H.; Li, P.; Huang, S.; Zhao, J.; Bao, M.
Disequilibrium of flavonol synthase and dihydroflavonol-4-reductase expression associated tightly to white vs. red color flower formation in plants
Front. Plant Sci.
6
1257
2015
Rosa rugosa (A0A096ZN44), Rosa rugosa, Prunus persica (A0A0C5DFB1), Prunus persica, Petunia x hybrida (Q07512), Petunia x hybrida, Nicotiana tabacum (Q1PHN5), Nicotiana tabacum
Vu, T.T.; Jeong, C.Y.; Nguyen, H.N.; Lee, D.; Lee, S.A.; Kim, J.H.; Hong, S.W.; Lee, H.
Characterization of Brassica napus flavonol synthase involved in flavonol biosynthesis in Brassica napus L
J. Agric. Food Chem.
63
7819-7829
2015
Brassica napus
Kallscheuer, N.; Vogt, M.; Bott, M.; Marienhagen, J.
Functional expression of plant-derived O-methyltransferase, flavanone 3-hydroxylase, and flavonol synthase in Corynebacterium glutamicum for production of pterostilbene, kaempferol, and quercetin
J. Biotechnol.
258
190-196
2017
Populus deltoides, Petunia x hybrida (Q07512)
Liu, S.; Liu, L.; Tang, Y.; Xiong, S.; Long, J.; Liu, Z.; Tian, N.
Comparative transcriptomic analysis of key genes involved in flavonoid biosynthetic pathway and identification of a flavonol synthase from Artemisia annua L
Plant Biol.
19
618-629
2017
Artemisia annua
Nguyen, N.H.; Kim, J.H.; Kwon, J.; Jeong, C.Y.; Lee, W.; Lee, D.; Hong, S.W.; Lee, H.
Characterization of Arabidopsis thaliana flavonol synthase 1 (FLS1)-overexpression plants in response to abiotic stress
Plant Physiol. Biochem.
103
133-142
2016
Arabidopsis thaliana (Q96330), Arabidopsis thaliana
Tian, J.; Han, Z.Y.; Zhang, J.; Hu, Y.; Song, T.; Yao, Y.
The balance of expression of dihydroflavonol 4-reductase and flavonol synthase regulates flavonoid biosynthesis and red foliage coloration in crabapples
Sci. Rep.
5
12228
2015
Malus hybrid cultivar (V5KXZ3)
Kim, Y.B.; Kim, K.; Kim, Y.; Tuan, P.A.; Kim, H.H.; Cho, J.W.; Park, S.U.
Cloning and characterization of a flavonol synthase gene from Scutellaria baicalensis
Sci. World J.
2014
980740
2014
Scutellaria baicalensis (V9PJ72), Scutellaria baicalensis
Zhang, C.; Liu, H.; Jia, C.; Liu, Y.; Wang, F.; Wang, J.
Cloning, characterization and functional analysis of a flavonol synthase from Vaccinium corymbosum
Trees
30
1595-1605
2016
Vaccinium corymbosum (A0A0G3FKU4)
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Akita, Y.; Kitamura, S.; Mikami, R.; Ishizaka, H.
Identification of functional flavonol synthase genes from fragrant wild cyclamen (Cyclamen purpurascens)
J. Plant Biochem. Biotechnol.
27
147-155
2018
Cyclamen purpurascens (A0A286T4M4), Cyclamen purpurascens (A0A286T529)
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