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1.14.20.6: flavonol synthase

This is an abbreviated version!
For detailed information about flavonol synthase, go to the full flat file.

Word Map on EC 1.14.20.6

Reaction

a dihydroflavonol
+
2-oxoglutarate
 +
O2
=
a flavonol
 +
succinate
 +
CO2
 +
H2O

Synonyms

AaFLS1, BnFLS, Cs-COR054, Cs-COR113, EC 1.14.11.23, FKS2, flavonoid 2-oxoglutarate-dependent dioxygenase, flavonol synthase, FLS, FLS1, FLS2, fls3, McFLS, NtFLS1, PhFLS, PpFLS, RrFLS1, SbFLS, VcFLS

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
                1.14.20.6 flavonol synthase

Expression

Expression on EC 1.14.20.6 - flavonol synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
anthocyanin levels shows a negatively correlation with the expression of flavonol synthase. Up-regulation of flavonol synthase expression expression results in fading leaf color
anthocyanin levels shows a positive correlation with the expression of dihydroflavonol 4-reductase
cold-stress treatment, 4°C for 24 h
-
ectopic expression of a heterologous flavonol synthase gene led to the significant down-regulation of endogenous Nicotiana tabacum dihydroflavonol-4-reductase expression in genetically transformed tobacco lines, and promotes Nicotiana tabacum flavonol synthase expression albeit weakly. Conversely,the overexpression of introduced dihydroflavonol-4-reductase genes suppresses the expression of Nicotiana tabacum flavonol synthase and promotes the expression of Nicotiana tabacum dihydroflavonol-4-reductase
expression is induced by salicylic acid
expression is suppressed by gibberellic acid
flavonol synthase FLS1 can be manipulated (i.e., silenced or overexpressed) to redirect the flavonoid biosynthetic pathway toward anthocyanin production without negative effects on plant growth and development
flavonol synthase FLS1 can be manipulated (i.e., silenced or overexpressed) to redirect the flavonoid biosynthetic pathway toward anthocyanin production without negative effects on plant growth and development. Overexpression of flavonol synthase FLS1 alters seed coat color (resulting in a light brown color), and also affects flavonoid accumulation. Flavonol synthase FLS1 overexpressing seedlings have lower levels of anthocyanin than those of the wild-type. Shoot tissues of flavonol synthase FLS1 overexpressiong plants exhibit lower flavonol levels than those of the wild-type
FtFLS1 expression is downregulated by NaCl, salicylic acid, and abscisic acid
GbFLS expression is induced by abiotic stresses: UV-B irradiation, abscisic acid, cold, sucrose, salicylic acid, and ethephon
increase at stage of pigmentation initiation
no effect on FLS2 expression by abscisic acid
the enzyme is UV-B-light-inducible in maize seedlings
-
the transcription level of FLS2 is significantlyup-regulated by salicylic acid and NaCl
wounding by cutting leaves induces maximum AcFLS mRNA accumulation 6-12 h after treatment