Reference on EC 1.14.11.66 - [histone H3]-trimethyl-L-lysine9 demethylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ng, S.S.; Kavanagh, K.L.; McDonough, M.A.; Butler, D.; Pilka, E.S.; Lienard, B.M.; Bray, J.E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N.R.; Offer, J.; Scheinost, J.C.; Borowski, T.; Sundstrom, M.; Schofield, C.J.; Oppermann, U.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Nature
448
87-91
2007
Homo sapiens (O75164), Homo sapiens
Ponnaluri, V.; Vavilala, D.; Putty, S.; Gutheil, W.; Mukherji, M.
Identification of non-histone substrates for JMJD2A-C histone demethylases
Biochem. Biophys. Res. Commun.
390
280-284
2009
Homo sapiens
Marmorstein, R.; Trievel, R.C.
Histone modifying enzymes: structures, mechanisms, and specificities
Biochim. Biophys. Acta
1789
58-68
2009
Homo sapiens (O60341)
Brasacchio, D.; Okabe, J.; Tikellis, C.; Balcerczyk, A.; George, P.; Baker, E.K.; Calkin, A.C.; Brownlee, M.; Cooper, M.E.; El-Osta, A.
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail
Diabetes
58
1229-1236
2009
Homo sapiens, Mus musculus
Sun, Q.; Zhou, D.
Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development
Proc. Natl. Acad. Sci. USA
105
13679-13684
2008
Oryza sativa (Q336N8), Oryza sativa
Yang, J.; Jubb, A.M.; Pike, L.; Buffa, F.M.; Turley, H.; Baban, D.; Leek, R.; Gatter, K.C.; Ragoussis, J.; Harris, A.L.
The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth
Cancer Res.
70
6456-6466
2010
Homo sapiens
Strobl-Mazzulla, P.H.; Sauka-Spengler, T.; Bronner-Fraser, M.
Histone demethylase JmjD2A regulates neural crest specification
Dev. Cell
19
460-468
2010
Gallus gallus
Bartova, E.; Stixova, L.; Galiova, G.; Harni?arova Horakova, A.; Legartova, S.; Kozubek, S.
Mutant genetic background affects the functional rearrangement and kinetic properties of JMJD2b histone demethylase
J. Mol. Biol.
405
679-695
2011
Mus musculus
Toyokawa, G.; Cho, H.; Iwai, Y.; Yoshimatsu, M.; Takawa, M.; Hayami, S.; Maejima, K.; Shimizu, N.; Tanaka, H.; Tsunoda, T.; Field, H.; Kelly, J.; Neal, D.; Ponder, B.; Maehara, Y.; Nakamura, Y.; Hamamoto, R.
The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6
Cancer Prev. Res. (Phila)
4
2051-2061
2011
Homo sapiens (O94953), Homo sapiens
Hillringhaus, L.; Yue, W.W.; Rose, N.R.; Ng, S.S.; Gileadi, C.; Loenarz, C.; Bello, S.H.; Bray, J.E.; Schofield, C.J.; Oppermann, U.
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
J. Biol. Chem.
286
41616-41625
2011
Homo sapiens (B2RXH2), Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q6B0I6), Homo sapiens (Q9H3R0), Homo sapiens
Ipenberg, I.; Guttmann-Raviv, N.; Khoury, H.P.; Kupershmit, I.; Ayoub, N.
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase
J. Biol. Chem.
288
14681-14687
2013
Homo sapiens
Verrier, L.; Escaffit, F.; Chailleux, C.; Trouche, D.; Vandromme, M.
A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation
PLoS Genet.
7
e1001390
2011
Homo sapiens
Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; Xuan, C.; Yao, Z.; Shang, Y.
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
Proc. Natl. Acad. Sci. USA
108
7541-7546
2011
Homo sapiens
Hancock, R.L.; Masson, N.; Dunne, K.; Flashman, E.; Kawamura, A.
The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
ACS Chem. Biol.
12
1011-1019
2017
Homo sapiens (O75164)
Morera, L.; Roatsch, M.; Fuerst, M.C.; Hoffmann, I.; Senger, J.; Hau, M.; Franz, H.; Schuele, R.; Heinrich, M.R.; Jung, M.
4-biphenylalanine- and 3-phenyltyrosine-derived hydroxamic acids as inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A
ChemMedChem
11
2063-2083
2016
Homo sapiens (O75164), Homo sapiens
Pedersen, M.T.; Kooistra, S.M.; Radzisheuskaya, A.; Laugesen, A.; Johansen, J.V.; Hayward, D.G.; Nilsson, J.; Agger, K.; Helin, K.
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
EMBO J.
35
1550-1564
2016
Mus musculus (Q8BW72), Mus musculus (Q8VCD7), Mus musculus (Q91VY5), Mus musculus, Mus musculus C57BL/6 (Q8BW72), Mus musculus C57BL/6 (Q8VCD7), Mus musculus C57BL/6 (Q91VY5)
Liu, Z.; Chen, X.; Zhou, S.; Liao, L.; Jiang, R.; Xu, J.
The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function
Int. J. Biol. Sci.
11
494-507
2015
Mus musculus (Q6ZPY7), Mus musculus C57BL/6 (Q6ZPY7)
Bavetsias, V.; Lanigan, R.M.; Ruda, G.F.; Atrash, B.; McLaughlin, M.G.; Tumber, A.; Mok, N.Y.; Le Bihan, Y.V.; Dempster, S.; Boxall, K.J.; Jeganathan, F.; Hatch, S.B.; Savitsky, P.; Velupillai, S.; Krojer, T.; England, K.S.; Sejberg, J.; Thai, C.; Donovan, A.; Pal, A.; Scozzafava, G.; Bennett, J.M.; Kawamu, A.
8-Substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors
J. Med. Chem.
59
1388-1409
2016
Homo sapiens (O75164), Homo sapiens (O94953)
Gacek-Matthews, A.; Noble, L.M.; Gruber, C.; Berger, H.; Sulyok, M.; Marcos, A.T.; Strauss, J.; Andrianopoulos, A.
KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans
Mol. Microbiol.
96
839-860
2015
Aspergillus nidulans (Q5BEH0), Aspergillus nidulans, Aspergillus nidulans ATCC 38163 (Q5BEH0), Aspergillus nidulans CBS 112.46 (Q5BEH0), Aspergillus nidulans FGSC A4 (Q5BEH0), Aspergillus nidulans M139 (Q5BEH0), Aspergillus nidulans NRRL 194 (Q5BEH0)
Yuan, X.; Kong, J.; Ma, Z.; Li, N.; Jia, R.; Liu, Y.; Zhou, F.; Zhan, Q.; Liu, G.; Gao, S.
KDM4C, a H3K9me3 histone demethylase, is involved in the maintenance of human ESCC-initiating cells by epigenetically enhancing SOX2 expression
Neoplasia
18
594-609
2016
Homo sapiens (Q9H3R0), Homo sapiens
Zoabi, M.; Nadar-Ponniah, P.T.; Khoury-Haddad, H.; Usaj, M.; Budowski-Tal, I.; Haran, T.; Henn, A.; Mandel-Gutfreund, Y.; Ayoub, N.
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation
Nucleic Acids Res.
42
13026-13038
2014
Homo sapiens, Homo sapiens (Q6B0I6)
Kupershmit, I.; Khoury-Haddad, H.; Awwad, S.W.; Guttmann-Raviv, N.; Ayoub, N.
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
Nucleic Acids Res.
42
6168-6182
2014
Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q9H3R0)
An, J.; Xu, J.; Li, J.; Jia, S.; Li, X.; Lu, Y.; Yang, Y.; Lin, Z.; Xin, X.; Wu, M.; Zheng, Q.; Pu, H.; Gui, X.; Li, T.; Lu, D.
HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372
Oncotarget
8
49093-49109
2017
Homo sapiens (O75164)
Jang, M.K.; Kim, J.H.; Jung, M.H.
Histone H3K9 demethylase JMJD2B activates adipogenesis by regulating H3K9 methylation on PPARgamma and C/EBPalpha during adipogenesis
PLoS ONE
12
e0168185
2017
Homo sapiens (O94953)
Ponnaluri, V.; Vavilala, D.; Putty, S.; Gutheil, W.; Mukherji, M.
Identification of non-histone substrates for JMJD2A-C histone demethylases
Biochem. Biophys. Res. Commun.
390
280-284
2009
Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q9H3R0)
Li, W.; Zhao, L.; Zang, W.; Liu, Z.; Chen, L.; Liu, T.; Xu, D.; Jia, J.
Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
Biochem. Biophys. Res. Commun.
416
372-378
2011
Homo sapiens (O94953)
-
Marmorstein, R.; Trievel, R.C.
Histone modifying enzymes structures, mechanisms, and specificities
Biochim. Biophys. Acta
1789
58-68
2009
Homo sapiens (O75164)
Gupta, J.; Kumar, S.; Li, J.; Krishna Murthy Karuturi, R.; Tikoo, K.
Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1) distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells
Biochimie
94
2656-2664
2012
Mus musculus (Q91VY5)
Iwamori, N.; Zhao, M.; Meistrich, M.L.; Matzuk, M.M.
The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility
Biol. Reprod.
84
1225-1234
2011
Mus musculus (Q3U2K5), Mus musculus
Li, Q.; Ke, Q.; Costa, M.
Alterations of histone modifications by cobalt compounds
Carcinogenesis
30
1243-1251
2009
Homo sapiens (O75164), Homo sapiens
Black, J.C.; Manning, A.L.; Van Rechem, C.; Kim, J.; Ladd, B.; Cho, J.; Pineda, C.M.; Murphy, N.; Daniels, D.L.; Montagna, C.; Lewis, P.W.; Glass, K.; Allis, C.D.; Dyson, N.J.; Getz, G.; Whetstine, J.R.
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors
Cell
154
541-555
2013
Homo sapiens (O75164)
Strobl-Mazzulla, P.H.; Sauka-Spengler, T.; Bronner-Fraser, M.
Histone demethylase JmjD2A regulates neural crest specification
Dev. Cell
19
460-468
2010
Gallus gallus (E1C6D5)
Lorbeck, M.T.; Singh, N.; Zervos, A.; Dhatta, M.; Lapchenko, M.; Yang, C.; Elefant, F.
The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
Gene
450
8-17
2009
Drosophila melanogaster (Q9V333)
Loh, Y.; Zhang, W.; Chen, X.; George, J.; Ng, H.
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
Genes Dev.
21
2545-2557
2007
Mus musculus (Q8VCD7)
Hillringhaus, L.; Yue, W.W.; Rose, N.R.; Ng, S.S.; Gileadi, C.; Loenarz, C.; Bello, S.H.; Bray, J.E.; Schofield, C.J.; Oppermann, U.
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family
J. Biol. Chem.
286
41616-41625
2011
Homo sapiens (B2RXH2), Homo sapiens (O75164), Homo sapiens (O94953), Homo sapiens (Q6B0I6), Homo sapiens (Q9H3R0), Homo sapiens
Tan, M.K.; Lim, H.J.; Harper, J.W.
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation
Mol. Cell. Biol.
31
3687-3699
2011
Homo sapiens
Couture, J.; Collazo, E.; Ortiz-Tello, P.A.; Brunzelle, J.S.; Trievel, R.C.
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase
Nat. Struct. Mol. Biol.
14
689-695
2007
Homo sapiens (O75164)
Klose, R.J.; Yamane, K.; Bae, Y.; Zhang, D.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y.
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
Nature
442
312-316
2006
Homo sapiens
Ng, S.S.; Kavanagh, K.L.; McDonough, M.A.; Butler, D.; Pilka, E.S.; Lienard, B.M.; Bray, J.E.; Savitsky, P.; Gileadi, O.; von Delft, F.; Rose, N.R.; Offer, J.; Scheinost, J.C.; Borowski, T.; Sundstrom, M.; Schofield, C.J.; Oppermann, U.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Nature
448
87-91
2007
Homo sapiens (O75164), Homo sapiens
Tateishi, K.; Okada, Y.; Kallin, E.; Zhang, Y.
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
Nature
458
757-761
2009
Mus musculus (Q6PCM1)
Das, N.D.; Choi, M.R.; Jung, K.H.; Park, J.H.; Lee, H.T.; Das, A.; Kim, S.H.; Chai, Y.G.
Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs)
Neurotox. Res.
23
154-165
2013
Mus musculus (Q91VY5), Mus musculus
Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
Characterization of Drosophila melanogaster JmjC+N histone demethylases
Nucleic Acids Res.
36
2852-2863
2008
Drosophila melanogaster (Q9V333), Drosophila melanogaster (Q9V6L0), Drosophila melanogaster
Verrier, L.; Escaffit, F.; Chailleux, C.; Trouche, D.; Vandromme, M.
A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation
PLoS Genet.
7
e1001390
2011
Homo sapiens (O75164)
Chen, Z.; Zang, J.; Kappler, J.; Hong, X.; Crawford, F.; Wang, Q.; Lan, F.; Jiang, C.; Whetstine, J.; Dai, S.; Hansen, K.; Shi, Y.; Zhang, G.
Structural basis of the recognition of a methylated histone tail by JMJD2A
Proc. Natl. Acad. Sci. USA
104
10818-10823
2007
Homo sapiens (O75164)
Young, L.C.; Hendzel, M.J.
The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression
Biochem. Cell Biol.
91
369-377
2013
Mus musculus
Holowatyj, A.; Yang, Z.
The role of histone demethylase GASC1 in cancer and its therapeutic potential
Curr. Cancer. Ther. Rev.
9
78-85
2013
Homo sapiens
-
Sudo, G.; Kagawa, T.; Kokubu, Y.; Inazawa, J.; Taga, T.
Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice
Genes Cells
21
218-225
2016
Mus musculus
Jeong, Y.S.; Park, J.S.; Ko, Y.; Kang, Y.K.
JHDM3A module as an effector molecule in guide-directed modification of target chromatin
J. Biol. Chem.
286
4461-4470
2011
Homo sapiens
Jiang, Y.; Li, C.; Wu, Q.; An, P.; Huang, L.; Wang, J.; Chen, C.; Chen, X.; Zhang, F.; Ma, L.; Liu, S.; He, H.; Xie, S.; Sun, Y.; Liu, H.; Zhan, Y.; Tao, Y.; Liu, Z.; Sun, X.; Hu, Y.; Wang, Q.; Ye, D.; Zhang, J.; Zou, S.; Wang, Y.; Wei, G.; Liu, Y.; Shi, Y.; Eugene Chin, Y.; Hao, Y.; Wang, F.; Zhang, X.
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses
Nat. Commun.
10
2935
2019
Mus musculus
Kim, T.D.; Oh, S.; Shin, S.; Janknecht, R.
Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D
PLoS ONE
7
e34618
2012
Homo sapiens
Tsurumi, A.; Dutta, P.; Dutta, P.; Shang, R.; Yan, S.J.; Sheng, R.; Li, W.X.
Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling
Sci. Rep.
3
2894
2013
Drosophila melanogaster
Kim, J.H.; Jung, D.Y.; Nagappan, A.; Jung, M.H.
Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARgamma2
Sci. Rep.
8
13734
2018
Homo sapiens, Mus musculus
Agger, K.; Nishimura, K.; Miyagi, S.; Messling, J.E.; Rasmussen, K.D.; Helin, K.
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
Blood
134
1154-1158
2019
Mus musculus (Q91VY5)
Li, M.; Cheng, J.; Ma, Y.; Guo, H.; Shu, H.; Huang, H.; Kuang, Y.; Yang, T.
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling
Cancer Cell Int.
20
101
2020
Homo sapiens (O75164), Homo sapiens
Xiang, Y.; Yan, K.; Zheng, Q.; Ke, H.; Cheng, J.; Xiong, W.; Shi, X.; Wei, L.; Zhao, M.; Yang, F.; Wang, P.; Lu, X.; Fu, L.; Lu, X.; Li, F.
Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1
Cancer Res.
79
86-98
2019
Homo sapiens (O94953)
Cui, S.Z.; Lei, Z.Y.; Guan, T.P.; Fan, L.L.; Li, Y.Q.; Geng, X.Y.; Fu, D.X.; Jiang, H.W.; Xu, S.H.
Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy
Cancer Sci.
111
1567-1581
2020
Mus musculus (Q8BW72), Mus musculus
Jones, D.; Wilson, L.; Thomas, H.; Gaughan, L.; Wade, M.A.
The histone demethylase enzymes KDM3A and KDM4B co-operatively regulate chromatin transactions of the estrogen receptor in breast cancer
Cancers (Basel)
11
1122
2019
Homo sapiens (O94953)
Ding, G.; Xu, X.; Li, D.; Chen, Y.; Wang, W.; Ping, D.; Jia, S.; Cao, L.
Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation
Cell Death Dis.
11
893
2020
Homo sapiens (O75164)
Qi, Q.; Wang, Y.; Wang, X.; Yang, J.; Xie, Y.; Zhou, J.; Li, X.; Wang, B.
Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPalpha and canonical Wnt signaling
Cell. Mol. Life Sci.
77
2407-2421
2020
Mus musculus (Q8BW72)
Zhou, J.; Wang, F.; Xu, C.; Zhou, Z.; Zhang, W.
The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice
Exp. Cell Res.
361
155-162
2017
Mus musculus (Q8BW72), Mus musculus
Kim, Y.; Lee, D.; Choi, Y.; Jeong, J.; Kwon, S.
Benzo[b]tellurophenes as a potential histone H3 lysine 9 demethylase (KDM4) inhibitor
Int. J. Mol. Sci.
20
5098
2019
Homo sapiens (O75164)
Hu, F.; Li, H.; Liu, L.; Xu, F.; Lai, S.; Luo, X.; Hu, J.; Yang, X.
Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1beta/VEGFA signalling
Mol. Cancer
17
107
2018
Homo sapiens (Q6B0I6), Homo sapiens
Voon, H.P.J.; Udugama, M.; Lin, W.; Hii, L.; Law, R.H.P.; Steer, D.L.; Das, P.P.; Mann, J.R.; Wong, L.H.
Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
Nat. Commun.
9
3142
2018
Mus musculus (Q91VY5)
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