Application | Comment | Organism |
---|---|---|
medicine | JMJD2B is a feasible molecular target for anticancer therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
JMJD2B quantitative real-time PCR expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94953 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung cancer cell | elevated activity of JMJD2B expression | Homo sapiens | - |
urinary bladder cancer cell | elevated levels of JMJD2B expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone demethylase | - |
Homo sapiens |
JMJD2B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | siRNA-mediated reduction of expression of JMJD2B in bladder and lung cancer cell lines significantly suppresses the proliferation of cancer cells, and suppressing JMJD2B expression leads to a decreased population of cancer cells in S phase, with a concomitant increase of cells in G1 phase | Homo sapiens |
metabolism | expression levels of JMJD2B and CDK6 were significantly correlated in various types of cell lines | Homo sapiens |
physiological function | histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6, transactivation of JMJD2B in lung cancer, elevated levels of JMJD2B expression in bladder cancer. The demethylase activity of JMJD2B possesses an oncogenic activity | Homo sapiens |