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Literature summary for 1.14.11.66 extracted from

  • Voon, H.P.J.; Udugama, M.; Lin, W.; Hii, L.; Law, R.H.P.; Steer, D.L.; Das, P.P.; Mann, J.R.; Wong, L.H.
    Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma (2018), Nat. Commun., 9, 3142 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine histone H3.3 G34R substitution mutation, found in paediatric gliomas, causes widespread changes in H3K9me3 and H3K36me3 level by interfering with the KDM4 family of K9/K36 demethylases. Expression of a targeted single-copy of H3.3 G34R at endogenous levels induces chromatin alterations that are comparable to a KDM4 A/B/C triple-knockout. H3.3 G34R preferentially binds KDM4 while simultaneously inhibiting its enzymatic activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q91VY5
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General Information

General Information Comment Organism
physiological function histone H3.3 G34R substitution mutation, found in paediatric gliomas, causes widespread changes in H3K9me3 and H3K36me3 level by interfering with the KDM4 family of K9/K36 demethylases. Expression of a targeted single-copy of H3.3 G34R at endogenous levels induces chromatin alterations that are comparable to a KDM4 isoforms A/B/C triple-knockout. H3.3 G34R preferentially binds KDM4 while simultaneously inhibiting its enzymatic activity Mus musculus