Literature summary for 1.14.11.66 extracted from

Jones, D.; Wilson, L.; Thomas, H.; Gaughan, L.; Wade, M.A.
The histone demethylase enzymes KDM3A and KDM4B co-operatively regulate chromatin transactions of the estrogen receptor in breast cancer (2019), Cancers (Basel), 11, 1122 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O94953	isoform KDM4B	-

General Information

General Information	Comment	Organism
physiological function	histone H3 lysine 9 demethylase enzymes, KDM3A, EC 1.14.11.66, and KDM4B cooperate to regulate ER activity via an autoregulatory loop that facilitates the recruitment of each coactivating enzyme to chromatin. KDM3A primes chromatin for deposition of the ER pioneer factor FOXA1 and recruitment of the ER-transcriptional complex, all prior to ER recruitment. A KDM3A/KDM4B/FOXA1 coregulated gene signature is enriched for proproliferative and ER-target gene sets. Depletion of both KDM3A and KDM4B has a greater inhibitory effect on ER activity and cell growth than knockdown of each individual enzyme	Homo sapiens

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Release 2023.1 (January 2023)