1.14.18.11: plant 4alpha-monomethylsterol monooxygenase

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For detailed information about plant 4alpha-monomethylsterol monooxygenase, go to the full flat file.

Reaction

Synonyms

4alpha-methyl oxidase, 4alpha-methyl-DELTA7-sterol-4alpha-methyl-oxidase, 4alpha-methylsterol C4 oxidase, 4alpha-methylsterol-4alpha-methyl-oxidase, 4alpha-MSO, methylsterol monooxygenase 2, SMO2, SMO2-1, SMO2-2, sterol-4alpha-methyl oxidase 2

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.18.11 plant 4alpha-monomethylsterol monooxygenase

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5	AA Sequence
5	Cloned(Commentary)
8	Cofactor
3	General Information
2	IC50 Value
9	Inhibitors
2	Localization
3	Metals/Ions
5	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
1	Protein Variants
4	Reaction
10	Reference
3	Source Tissue
26	Substrates and Products (Substrate)
3	Subunits
21	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.18.11 - plant 4alpha-monomethylsterol monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

24-ethylidenelophenol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating)

This plant enzyme catalyses a step in the biosynthesis of sterols. It acts on the methyl group of the 4alpha-methylated intermediates 24-ethylidenelophenol and 24-methylidenelophenol and catalyses three successive oxidations, turning it into a carboxyl group. The carboxylate is subsequently removed by EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating). Unlike the fungal/animal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, this enzyme is not able to act on 4,4-dimethylated substrates. That activity, which occurs earlier in the pathway, is performed in plants by a second enzyme, EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase.