2.3.1.293: meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

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For detailed information about meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I, go to the full flat file.

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Synonyms

beta-ketoacyl ACP synthase, beta-ketoacyl ACP synthase I, beta-ketoacyl acyl carrier protein synthase, beta-ketoacyl-ACP synthase, beta-ketoacyl-AcpM synthase, beta-ketoacyl-AcpM synthase A, beta-ketoacyl-acyl carrier protein synthase, beta-ketoacyl-acyl carrier protein synthase KasA, beta-ketoacyl-acyl-carrier protein synthase, beta-ketoacylacyl synthase, KasA, Rv2245

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.293 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

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Results	in table
1	Activating Compound
5	AA Sequence
6	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
9	General Information
3	IC50 Value
26	Inhibitors
4	kcat/KM [mM/s]
17	Ki Value [mM]
6	KM Value [mM]
2	Localization
14	Natural Substrates/ Products (Substrates)
591	Organism
1	Pathway
1	pH Optimum
15	Protein Variants
4	Purification (Commentary)
1	Reaction
16	Reference
2	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
8	Subunits
38	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.293 - meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

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SYSTEMATIC NAME

IUBMB Comments

ultra-long-chain mono-unsaturated fattyl acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)

The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasA differs from KasB [EC 2.3.1.294, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II], by preferring shorter (C-22 to C-36) and more saturated (only one double bond) substrates.