2.3.1.293: meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I
This is an abbreviated version!
For detailed information about meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I, go to the full flat file.
Word Map on EC 2.3.1.293
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2.3.1.293
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polyketide
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cerulenin
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malonyl
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isoniazid
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6-deoxyerythronolide
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condensing
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mycolic
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diketide
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malonyl-acp
- 2.3.1.293
- polyketide
- cerulenin
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malonyl
- isoniazid
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6-deoxyerythronolide
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condensing
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mycolic
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diketide
- malonyl-acp
Reaction
Synonyms
beta-ketoacyl ACP synthase, beta-ketoacyl ACP synthase I, beta-ketoacyl acyl carrier protein synthase, beta-ketoacyl-ACP synthase, beta-ketoacyl-AcpM synthase, beta-ketoacyl-AcpM synthase A, beta-ketoacyl-acyl carrier protein synthase, beta-ketoacyl-acyl carrier protein synthase KasA, beta-ketoacyl-acyl-carrier protein synthase, beta-ketoacylacyl synthase, KasA, Rv2245
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General Information
General Information on EC 2.3.1.293 - meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I
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malfunction
metabolism
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depletion of the enzyme leads to mycobacterial cell lysis and inhibition of alpha and epoxy mycolate biosynthesis and to accumulation of alpha'-mycolates
malfunction
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depletion of the enzyme leads to mycobacterial cell lysis and inhibition of alpha and epoxy mycolate biosynthesis and to accumulation of alpha'-mycolates
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an essential enzyme in the mycobacterial fatty acid biosynthesis (FAS-II) pathway, type II fatty acid biosynthesis pathway overview
metabolism
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the enzyme is involved in fatty acid and mycolic acid biosynthesis
metabolism
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when KasB is coexpressed with enzyme KasA, it appears to be capable of facilitating the production of lipids of the length of full meromycolic acids. KasB therefore may accept primers directly from KasA that average 40 carbons in length. KasA and KasB thus function in tandem to carrier out acyl chain elongation to achieve meromycolic acid synthesis from acyl primers provided by type I fatty acid synthase system
metabolism
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the enzyme is involved in fatty acid and mycolic acid biosynthesis
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metabolism
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when KasB is coexpressed with enzyme KasA, it appears to be capable of facilitating the production of lipids of the length of full meromycolic acids. KasB therefore may accept primers directly from KasA that average 40 carbons in length. KasA and KasB thus function in tandem to carrier out acyl chain elongation to achieve meromycolic acid synthesis from acyl primers provided by type I fatty acid synthase system
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