2.3.1.293: meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

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For detailed information about meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I, go to the full flat file.

Word Map on EC 2.3.1.293

2.3.1.293

polyketide

cerulenin

malonyl

isoniazid

6-deoxyerythronolide

condensing

mycolic

diketide

malonyl-acp

Reaction

an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein]

an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein]

Synonyms

beta-ketoacyl ACP synthase, beta-ketoacyl ACP synthase I, beta-ketoacyl acyl carrier protein synthase, beta-ketoacyl-ACP synthase, beta-ketoacyl-AcpM synthase, beta-ketoacyl-AcpM synthase A, beta-ketoacyl-acyl carrier protein synthase, beta-ketoacyl-acyl carrier protein synthase KasA, beta-ketoacyl-acyl-carrier protein synthase, beta-ketoacylacyl synthase, KasA, Rv2245

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.293 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

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Results	in table
1	Activating Compound
5	AA Sequence
6	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
9	General Information
3	IC50 Value
26	Inhibitors
4	kcat/KM [mM/s]
17	Ki Value [mM]
6	KM Value [mM]
2	Localization
14	Natural Substrates/ Products (Substrates)
591	Organism
1	Pathway
1	pH Optimum
15	Protein Variants
4	Purification (Commentary)
1	Reaction
16	Reference
2	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
8	Subunits
38	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.293 - meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I

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an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]

a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

Mycobacterium tuberculosis

736441

an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]

an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

6 entries

an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein AcpM]

an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein AcpM]

Mycobacterium tuberculosis

754094

an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + palmitoyl-[acyl-carrier protein AcpM]

an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein AcpM]

Mycobacterium tuberculosis

754094

additional information

2 entries