1.14.14.95: germacrene A hydroxylase

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For detailed information about germacrene A hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.95

1.14.14.95

sesquiterpene

lactone

costunolide

asteraceae

synthases

terpene

cos

feverfew

chicory

parthenolide

1-deoxy-d-xylulose-5-phosphate

spinosa

reductoisomerase

tanacetum

benthamiana

amorphadiene

artemisinic

+-germacrene

parthenium

sunflower

Reaction

+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =

+ 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

Synonyms

(+)-germacrene A hydroxylase, EC 1.1.1.314, EC 1.14.13.123, GAO, germacrene A oxidase, NADP+-dependent sesquiterpenoid dehydrogenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.95 germacrene A hydroxylase

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Results	in table
13	AA Sequence
6	Cloned(Commentary)
8	Cofactor
7	Inhibitors
1	Localization
5	Molecular Weight [Da]
6	Organism
4	Pathway
1	pH Optimum
1	pH Range
4	Reaction
1	Reaction Type
6	Reference
2	Source Tissue
10	Substrates and Products (Substrate)
14	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.14.95 - germacrene A hydroxylase

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(+)-germacrene-A,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating)

A cytochrome P-450 (heme-thiolate) protein. This plant enzyme catalyses three steps in a pathway that leads to the biosynthesis of many sesquiterpenoid lactones.