Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.14.95: germacrene A hydroxylase

This is an abbreviated version!
For detailed information about germacrene A hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.95

Reaction

(+)-germacrene A
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =
germacra-1(10),4,11(13)-trien-12-oate
 + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

Synonyms

(+)-germacrene A hydroxylase, EC 1.1.1.314, EC 1.14.13.123, GAO, germacrene A oxidase, NADP+-dependent sesquiterpenoid dehydrogenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.95 germacrene A hydroxylase

Inhibitors

Inhibitors on EC 1.14.14.95 - germacrene A hydroxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
aminobenzotriazole
-
26% inhibition at 0.1 mM
carbon monoxide
-
blue-light reversible inhibition, an atmosphere of 80% CO plus 20% O2 inhibits (+)-germacrene A hydroxylase by 69%
clotrimazole
-
016% inhibition at 0.1 mM
cytochrome c
-
97% inhibition at 0.1 mM
Metyrapone
-
23% inhibition at 1 mM
miconazole
-
30% inhibition at 0.1 mM
additional information
-
flushing the reaction mixture for 1.5 min with argon prior to incubation causes a 69% decrease of enzyme activity because of O2 depletion
-