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1.14.14.95: germacrene A hydroxylase

This is an abbreviated version!
For detailed information about germacrene A hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.95

Reaction

(+)-germacrene A
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =
germacra-1(10),4,11(13)-trien-12-oate
+ 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

Synonyms

(+)-germacrene A hydroxylase, EC 1.1.1.314, EC 1.14.13.123, GAO, germacrene A oxidase, NADP+-dependent sesquiterpenoid dehydrogenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.95 germacrene A hydroxylase

Reference

Reference on EC 1.14.14.95 - germacrene A hydroxylase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nguyen, D.; Goepfert, J.; Ikezawa, N.; MacNevin, G.; Kathiresan, M.; Conrad, J.; Spring, O.; Ro, D.
Biochemical conservation and evolution of germacrene A oxidase in Asteraceae
J. Biol. Chem.
285
16588-16598
2010
Lactuca sativa (D5J9U8), Cichorium intybus (D5JBW8), Cichorium intybus, Saussurea costus (D5JBW9), Helianthus annuus (D5JBX0), Barnadesia spinosa (D5JBX1), Barnadesia spinosa
Manually annotated by BRENDA team
De Kraker, K.J.; Franssen, M.; Dalm, M.; de, G.A.; Bouwmeester, H.
Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis
Plant Physiol.
125
1930-1940
2001
Cichorium intybus
Manually annotated by BRENDA team