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1.14.14.92: benzoate 4-monooxygenase

This is an abbreviated version!
For detailed information about benzoate 4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.92

Reaction

benzoate
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
4-hydroxybenzoate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

An09g03500, benzoate 1,2-dioxygenase, benzoate 4-hydroxylase, benzoate para-hydroxylase, benzoate-4-hydroxylase, benzoate-p-hydroxylase, benzoic 4-hydroxylase, benzoic acid 4-hydroxylase, BphA, Cyp1, CYP53A15, CYP53B1, EC 1.14.13.12, hydroxylase, benzoate 4-, More, oxygenase, benzoate 4-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.92 benzoate 4-monooxygenase

Inhibitors

Inhibitors on EC 1.14.14.92 - benzoate 4-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-1-(4-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one
competitive inhibitor
2,2'-dipyridyl
-
0.05 mM; 50% inhibition
2-phenylpyrimidine-5-carboxylic acid
second best inhibitor among hit compounds, good behaviour in the spectral binding assay but weak antifungal activity
3-methyl-4-(1H-pyrrol-1-yl)benzoic acid
best inhibitor among hit compounds, best in the spectral binding assay and has second best antifungal activity
4-Chlorobenzoate
-
-
4-Methylbenzoate
-
-
4-nitrobenzoate
-
38% inhibition
8-hydroxyquinoline
-
5 mM, complete inhibition
aminopterin
-
0.5 mM, 10% inhibition
benzaldehyde
-
-
benzoate methyl ester
-
slight inhibition
Benzyl acetate
-
0.5 mM, 21% inhibition
benzyl alcohol
-
0.5 mM, 10% inhibition
benzylformate
-
0.5 mM, 10% inhibition
diethyldithiocarbamate
iodoacetamide
-
5 mM, 43% inhibition
iodoacetate
-
5 mM, 23% inhibition
KCN
-
30 mM, 21% inhibition
m-Hydroxybenzoate
Mg2+
-
0.001-0.01 mM, complete inhibition
Mn2+
-
0.001-0.01 mM, complete inhibition
Mo2+
-
0.001-0.01 mM, complete inhibition
N-ethylmaleimide
-
-
o-phenanthroline
-
0.05 mM, 70% inhibition
oxalate
-
2 mM, 20% inhibition
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
0.052 mM, 39% inhibition
phenylalanine
-
0.5 mM, 21% inhibition
Quinacrine
-
0.5 mM, 47% inhibition
quinine-HCl
-
0.5 mM, 42% inhibition
salicylate
SKF-525A
-
cytochorme P450 inhibitor, 1 mM, 51% inhibition
trans-cinnamate
-
0.5 mM, 55% inhibition
Zn2+
-
0.001-0.01 mM, complete inhibition