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2-chlorobenzoate + [reduced NADPH-hemoprotein reductase] + O2
2-chloro-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
2-fluorobenzoate + [reduced NADPH-hemoprotein reductase] + O2
2-fluoro-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
2-hydroxybenzoate + [reduced NADPH-hemoprotein reductase] + O2
2,4-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
2-methylbenzoate + [reduced NADPH-hemoprotein reductase] + O2
2-methyl-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
2-methylbenzoic acid + NADPH + O2
4-hydroxy-2-methylbenzoic acid + NADP+ + H2O
-
-
-
?
3-chlorobenzoate + [reduced NADPH-hemoprotein reductase] + O2
3-chloro-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
3-fluorobenzoate + [reduced NADPH-hemoprotein reductase] + O2
3-fluoro-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
3-hydroxybenzoate + [reduced NADPH-hemoprotein reductase] + O2
3,4-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
3-hydroxybenzoic acid + [reduced NADPH-hemoprotein reductase] + O2
3,4-dihydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
reaction of 3-hydroxybenzoate 4-monooxygenase, EC 1.14.13.23
-
-
?
3-methoxybenzoate + [reduced NADPH-hemoprotein reductase] + O2
3-methoxy-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
3-methylbenzoate + [reduced NADPH-hemoprotein reductase] + O2
3-methyl-4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
3-methylbenzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxy-3-methylbenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
4-chlorobenzoate + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
4-methylbenzoate + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
benzoate + 6,7-dimethyltetrahydropterin + O2
4-hydroxybenzoate + oxidized 6,7-dimethyltetrahydropterin + H2O
-
-
-
-
r
benzoate + NADH + H+ + O2
4-hydroxybenzoate + NAD+ + H2O
-
-
-
-
r
benzoate + NADPH + H+ + O2
4-hydroxybenzoate + NADP+ + H2O
benzoate + [reduced NADPH-hemoprotein reductase] + O2
2-hydro-1,2-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
cinnamate + [reduced NADPH-hemoprotein reductase] + O2
4-coumarate + [oxidized NADPH-hemoprotein reductase] + H2O
-
very low turnover rate
-
?
nicotinate + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
picolinate + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
benzoate + NADPH + H+ + O2
4-hydroxybenzoate + NADP+ + H2O
-
-
-
-
r
benzoate + NADPH + H+ + O2
4-hydroxybenzoate + NADP+ + H2O
-
-
-
-
r
benzoate + NADPH + H+ + O2
4-hydroxybenzoate + NADP+ + H2O
-
-
-
-
r
benzoate + [reduced NADPH-hemoprotein reductase] + O2
2-hydro-1,2-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-benzoate dihydrodiol is subsequently dehydrogenated to catechol which is cleaved further
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
2-hydro-1,2-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-benzoate dihydrodiol is subsequently dehydrogenated to catechol which is cleaved further
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
specific for benzoate, NADPH is absolutely required, 30% activity with ascorbate as electron donor
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
enzyme is involved in degradation of chlorinated benzoic acid derivatives e.g. 2-chlorobenzoate and 3-chlorobenzoate
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
specific for benzoate, NADPH is absolutely required, 30% activity with ascorbate as electron donor
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
benzoic acid has a regulatory effect on the enzyme
-
-
?
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benzoate + [reduced NADPH-hemoprotein reductase] + O2
2-hydro-1,2-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
benzoate + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
enzyme is involved in degradation of chlorinated benzoic acid derivatives e.g. 2-chlorobenzoate and 3-chlorobenzoate
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
benzoate + [reduced NADPH-hemoprotein reductase] + O2
2-hydro-1,2-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-benzoate dihydrodiol is subsequently dehydrogenated to catechol which is cleaved further
-
?
benzoate + [reduced NADPH-hemoprotein reductase] + O2
2-hydro-1,2-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-benzoate dihydrodiol is subsequently dehydrogenated to catechol which is cleaved further
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
benzoic acid + [reduced NADPH-hemoprotein reductase] + O2
4-hydroxybenzoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
benzoic acid has a regulatory effect on the enzyme
-
-
?
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BPHA_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
517
1
58044
Swiss-Prot
Secretory Pathway (Reliability: 1)
BPHA_ASPNG
517
1
58016
Swiss-Prot
Secretory Pathway (Reliability: 1)
M5CD23_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
562
2
62357
TrEMBL
Secretory Pathway (Reliability: 2)
M5CA26_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
212
1
24024
TrEMBL
other Location (Reliability: 5)
M5CH82_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
241
0
26619
TrEMBL
other Location (Reliability: 1)
A2QBF9_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
563
1
62739
TrEMBL
Secretory Pathway (Reliability: 1)
B8QM33_COCLU
501
1
56798
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0F8B0U2_CERFI
494
0
57546
TrEMBL
other Location (Reliability: 1)
A0A0B7FYF3_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
466
1
51862
TrEMBL
Secretory Pathway (Reliability: 5)
A2QF47_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
474
1
54029
TrEMBL
Secretory Pathway (Reliability: 2)
A2QTT5_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
515
1
58571
TrEMBL
Secretory Pathway (Reliability: 4)
M5CEK5_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
241
0
26626
TrEMBL
other Location (Reliability: 1)
A2QJV6_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
518
1
59381
TrEMBL
Secretory Pathway (Reliability: 1)
B8MMA4_TALSN
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
516
2
57853
TrEMBL
Secretory Pathway (Reliability: 1)
A2QBA0_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
505
1
55776
TrEMBL
Secretory Pathway (Reliability: 2)
A2Q9Q2_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
518
1
58707
TrEMBL
Secretory Pathway (Reliability: 1)
V5Z129_9PEZI
504
1
56730
TrEMBL
Secretory Pathway (Reliability: 1)
M5BV61_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
345
1
38042
TrEMBL
Secretory Pathway (Reliability: 5)
A0A0F4YLL5_TALEM
578
3
65028
TrEMBL
Secretory Pathway (Reliability: 1)
Q39LN9_BURL3
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
413
0
45549
TrEMBL
-
A0A0F4Z427_TALEM
527
1
59484
TrEMBL
Secretory Pathway (Reliability: 2)
Q4WZZ5_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
519
1
58486
TrEMBL
Secretory Pathway (Reliability: 1)
Q6MYG4_ASPFM
586
1
65348
TrEMBL
other Location (Reliability: 2)
C5PCX3_COCP7
Coccidioides posadasii (strain C735)
516
1
58329
TrEMBL
Secretory Pathway (Reliability: 1)
M5CGD3_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
180
1
20201
TrEMBL
Secretory Pathway (Reliability: 2)
A2QZD1_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
588
3
65477
TrEMBL
Secretory Pathway (Reliability: 5)
A2QRJ4_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
476
0
52736
TrEMBL
Secretory Pathway (Reliability: 1)
M5CDI6_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
901
0
99519
TrEMBL
other Location (Reliability: 5)
A0A2S5BD01_9BASI
559
1
62614
TrEMBL
Secretory Pathway (Reliability: 3)
M5CCU6_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
521
1
57651
TrEMBL
other Location (Reliability: 5)
A2R8R2_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
507
1
57686
TrEMBL
Secretory Pathway (Reliability: 1)
A0A0B2RW13_GLYSO
682
0
76563
TrEMBL
other Location (Reliability: 1)
M5C331_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
416
1
45826
TrEMBL
other Location (Reliability: 3)
A8I4E8_9GAMM
456
0
51460
TrEMBL
-
A8I4F1_9GAMM
163
0
19290
TrEMBL
-
A8I4F4_9GAMM
342
0
37594
TrEMBL
-
B8QM33_COCLU
501
1
56798
TrEMBL
Secretory Pathway (Reliability: 1)
Q4H2B4_PHACH
536
0
60050
TrEMBL
-
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Durham, D.R.
Initial reactions involved in the dissimilation of mandelate by Rhodotorula graminis
J. Bacteriol.
160
778-780
1984
Rhodotorula graminis
brenda
McNamee, C.; Durham, D.R.
Properties of a membrane-associated benzoate-4-hydroxylase from Rhodotorula graminis
Biochem. Biophys. Res. Commun.
129
485-492
1985
Rhodotorula graminis
brenda
Reddy, C.C.; Vaidyanathan, C.S.
Purification and properties of benzoate-4-hydroxylase from a soil pseudomonad
Arch. Biochem. Biophys.
177
488-498
1976
Pseudomonas sp.
brenda
Reddy, C.C.; Vaidyanathan, C.S.
Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814)
Biochim. Biophys. Acta
384
46-57
1975
Aspergillus niger, Aspergillus niger UBC 814
brenda
Shailubhai, K.; Sahasrabudhe, S.R.; Vora, K.A.; Modi, V.V.
Degradation of chlorinated derivatives of phenoxyacetic acid and benzoic acid by Aspergillus niger
FEMS Microbiol. Lett.
18
279-282
1983
Aspergillus niger
-
brenda
Fukuda, H.; Nakamura, K.; Sukita, E.; Ogawa, T.; Fujii, T.
Cytochrome P450rm from Rhodotorula minuta catalyzes 4-hydroxylation of benzoate
J. Biochem.
119
314-318
1996
Cystobasidium minutum
brenda
Van Den Brink, J.M.; Van Den Hondel, C.A.M.J.J.; Van Gorcom, R.F.M.
Optimization of the benzoate-inducible benzoate p-hydroxylase cytochrome P450 enzyme system in Aspergillus niger
Appl. Microbiol. Biotechnol.
46
360-364
1996
Aspergillus niger, Aspergillus niger N204
brenda
Faber, B.W.; van Gorcom, R.F.; Duine, J.A.
Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger
Arch. Biochem. Biophys.
394
245-254
2001
Aspergillus niger
brenda
Shiningavamwe, A.; Obiero, G.; Albertyn, J.; Nicaud, J.M.; Smit, M.
Heterologous expression of the benzoate para-hydroxylase encoding gene (CYP53B1) from Rhodotorula minuta by Yarrowia lipolytica
Appl. Microbiol. Biotechnol.
72
323-329
2006
Cystobasidium minutum, Cystobasidium minutum CBS 2177
brenda
Matsuzaki, F.; Wariishi, H.
Molecular characterization of cytochrome P450 catalyzing hydroxylation of benzoates from the white-rot fungus Phanerochaete chrysosporium
Biochem. Biophys. Res. Commun.
334
1184-1190
2005
Phanerodontia chrysosporium (Q4H2B4)
brenda
Kim, D.; Kim, S.W.; Choi, K.Y.; Lee, J.S.; Kim, E.
Molecular cloning and functional characterization of the genes encoding benzoate and p-hydroxybenzoate degradation by the halophilic Chromohalobacter sp. strain HS-2
FEMS Microbiol. Lett.
280
235-241
2008
Chromohalobacter sp. HS-2 (A8I4E8), Chromohalobacter sp. HS-2 (A8I4F1), Chromohalobacter sp. HS-2 (A8I4F4), Chromohalobacter sp. HS2 (A8I4E8), Chromohalobacter sp. HS2 (A8I4F1), Chromohalobacter sp. HS2 (A8I4F4)
brenda
Berne, S.; Podobnik, B.; Zupanec, N.; Novak, M.; Krasevec, N.; Turk, S.; Korosec, B.; Lah, L.; Suligoj, E.; Stojan, J.; Gobec, S.; Komel, R.
Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase
J. Chem. Inf. Model.
52
3053-3063
2012
Curvularia lunata (B8QM33)
brenda
Antunes, M.S.; Hodges, T.K.; Carpita, N.C.
A benzoate-activated promoter from Aspergillus niger and regulation of its activity
Appl. Microbiol. Biotechnol.
100
5479-5489
2016
Aspergillus niger (P17549)
brenda
Korosec, B.; Sova, M.; Turk, S.; Krasevec, N.; Novak, M.; Lah, L.; Stojan, J.; Podobnik, B.; Berne, S.; Zupanec, N.; Bunc, M.; Gobec, S.; Komel, R.
Antifungal activity of cinnamic acid derivatives involves inhibition of benzoate 4-hydroxylase (CYP53)
J. Appl. Microbiol.
116
955-966
2014
Curvularia lunata (B8QM33), Curvularia lunata
brenda