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1.14.14.156: tryptophan N-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan N-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.156

Reaction

L-tryptophan
+ 2 [reduced NADPH-hemoprotein reductase] + 2 O2 =
(E)-indol-3-ylacetaldoxime
 + 2 [oxidized NADPH-hemoprotein reductase] +
CO2
 + 3 H2O

Synonyms

CYP79B1, CYP79B1 monooxygenase, CYP79B2, CYP79B3, EC 1.14.13.125

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.156 tryptophan N-monooxygenase

Systematic Name

Systematic Name on EC 1.14.14.156 - tryptophan N-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
L-tryptophan,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein from the plant Arabidopsis thaliana. This enzyme catalyses two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of both auxin and the indole alkaloid phytoalexin camalexin. The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme.