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1.14.14.156: tryptophan N-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan N-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.156

Reaction

L-tryptophan
+ 2 [reduced NADPH-hemoprotein reductase] + 2 O2 =
(E)-indol-3-ylacetaldoxime
 + 2 [oxidized NADPH-hemoprotein reductase] +
CO2
 + 3 H2O

Synonyms

CYP79B1, CYP79B1 monooxygenase, CYP79B2, CYP79B3, EC 1.14.13.125

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.156 tryptophan N-monooxygenase

Inhibitors

Inhibitors on EC 1.14.14.156 - tryptophan N-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-aminobenzotriazole
the activity of CYP79B2 is inhibited 18 and 75% by 0.4 mM and 4 mM 1-aminobenzotriazole
2,4-Dichlorophenol
800 mM 2,4-dichlorophenol added to the CYP79B2 reconstitution assay inhibits the activity by 72%
H2O2
100 mM H2O2 added to the CYP79B2 reconstitution assay inhibits the activity by 96%
MnCl2
1 mM MnCl2 added to the CYP79B2 reconstitution assay inhibits the activity by 34%
tetcyclasis
the activity of CYP79B2 is inhibited 54 and 76% by 0.02 and 0.2 mM tetcyclasis
additional information
CYP79B2 is not inhibited by Me2SO of a maximum concentration of 4% (v/v); the combination of 100 mM H2O2, 1 mM MnCl2, and 800 mM 2,4-dichlorophenol added to the reconstitution assay inhibits the CYP79B2 activity by 99%
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