1.14.14.156: tryptophan N-monooxygenase
This is an abbreviated version!
For detailed information about tryptophan N-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.156
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1.14.14.156
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glucosinolates
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indole
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camalexin
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indole-3-acetaldoxime
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phytoalexins
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cyp83b1
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myzus
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myrosinase
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indole-3-acetonitrile
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cyp81f2
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tryptophan-derived
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cyp79s
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microbe-associated
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indole-3-carboxylic
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plectosphaerella
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plant-insect
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cucumerina
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auxin-related
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yucca
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pieris
- 1.14.14.156
- glucosinolates
- indole
- camalexin
- indole-3-acetaldoxime
-
phytoalexins
- cyp83b1
-
myzus
- myrosinase
- indole-3-acetonitrile
-
cyp81f2
-
tryptophan-derived
- cyp79s
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microbe-associated
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indole-3-carboxylic
- plectosphaerella
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plant-insect
- cucumerina
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auxin-related
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yucca
-
pieris
Reaction
+ 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = + 2 [oxidized NADPH-hemoprotein reductase] + + 3 H2O
Synonyms
CYP79B1, CYP79B1 monooxygenase, CYP79B2, CYP79B3, EC 1.14.13.125
ECTree
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General Information
General Information on EC 1.14.14.156 - tryptophan N-monooxygenase
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malfunction
metabolism
physiological function
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cyp79B2/cyp79B3 double mutant has reduced levels of indole-3-acetic acid, shows growth defects consistent with partial auxin deficiency, and is hypersensitive to 5-methyltryptophan
malfunction
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depletion of tryptophan-derived metabolites in cyp79B2/cyp79B3 mutants renders Arabidopsis fully susceptible to non-adapted Plectosphaerella cucumerina isolates 1187 and 2127, and super-susceptible to the adapted Plectosphaerella cucumerina isolate BMM
malfunction
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the cyp79B2/cyp79B3 double knockout mutant is devoid of camalexin, as it is also devoid of indole glucosinolates
CYP79B2 is involved in indole glucosinolate biosynthesis. CYP79B2 functions in biosynthesis of indole-3-acetic acid
metabolism
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CYP79B2/CYP79B3 catalyse the first step of camalexin biosynthesis from L-tryptophan
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CYP79B2 and CYP79B3 are critical enzymes in auxin biosynthesis in vivo and play critical roles in indole-3-acetic acid biosynthesis
physiological function
CYP79B2, when overexpressed in Arabidopsis, confers resistance to toxic analogs of L-tryptophan like 5-methyltryptophan, 5-methylanthranilate, 5-fluoroindole, and 5-fluorotryptophan. In addition, CYP79B2 is expressed in response to bacterial pathogens. CYP79B2 metabolizes L-tryptophan to indole-3-acetaldoxime that can be used for either indole-3-acetic acid or indole glucosinolate biosynthesis
physiological function
CYP79B3 metabolize L-tryptophan to indole-3-acetaldoxime that can be used for either indole-3-acetic acid or indole glucosinolate biosynthesis
physiological function
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only CYP79B2 and CYP79B3 contribute significantly to the indole-3-acetaldoxime pool from which camalexin and indole glucosinolates are synthesized