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1.17.98.4: formate dehydrogenase (hydrogenase)

This is an abbreviated version!
For detailed information about formate dehydrogenase (hydrogenase), go to the full flat file.

Word Map on EC 1.17.98.4

Reaction

formate
+
an [oxidized hydrogenase]
=
CO2
 +
a [reduced hydrogenase]

Synonyms

benzylviologen-linked formate dehydrogenase, EC 1.1.99.33, EC 1.17.99.7, Fdh-H, FDH-O, fdhF gene product, FDHH, formate dehydrogenase (formate-hydrogen-lyase-linked), formate dehydrogenase H, formate dehydrogenase O, formate hydrogenlyase, methylviologen-dependent formate dehydrogenase, molybdenum-containing formate dehydrogenase H

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.98 With other, known, physiological acceptors
                1.17.98.4 formate dehydrogenase (hydrogenase)

Inhibitors

Inhibitors on EC 1.17.98.4 - formate dehydrogenase (hydrogenase)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
1,2-dihydroxybenzene-3,5-disulfonic acid
-
-
2,2'-dipyridyl
-
-
4,5-dihydroxybenzene-1,3-disulfonate
-
-
azide
-
0.3 mM NaN3, about 80% inhibition
formate
-
-
iodoacetamide
N3-
formate oxidation is inhibited strongly and competitively whereas CO2 reduction is inhibited weakly and not competitively; strongly inhibits the oxidation of formate, whereas CO2 reduction is inhibited only weakly and not competitively
NaNO3
-
competitive with respect to formate
nitrate
-
10 mM NaNO3, 50% inhibition
nitrite
-
10 mM NaNO2, 55% inhibition
NO2-
formate oxidation is inhibited strongly and competitively whereas CO2 reduction is inhibited weakly and not competitively; strongly inhibits the oxidation of formate, whereas CO2 reduction is inhibited only weakly and not competitively
NO3-
formate oxidation is inhibited strongly and competitively whereas CO2 reduction is inhibited weakly and not competitively; strongly inhibits the oxidation of formate, whereas CO2 reduction is inhibited only weakly and not competitively
OCN-
formate oxidation is inhibited strongly and competitively whereas CO2 reduction is inhibited weakly and not competitively; strongly inhibits the oxidation of formate, whereas CO2 reduction is inhibited only weakly and not competitively
SCN-
formate oxidation is inhibited strongly and competitively whereas CO2 reduction is inhibited weakly and not competitively; strongly inhibits the oxidation of formate, whereas CO2 reduction is inhibited only weakly and not competitively
Sodium azide
-
competitive with respect to formate