1.17.98.4: formate dehydrogenase (hydrogenase)

This is an abbreviated version!
For detailed information about formate dehydrogenase (hydrogenase), go to the full flat file.

Reaction

Synonyms

benzylviologen-linked formate dehydrogenase, EC 1.1.99.33, EC 1.17.99.7, Fdh-H, FDH-O, fdhF gene product, FDHH, formate dehydrogenase (formate-hydrogen-lyase-linked), formate dehydrogenase H, formate dehydrogenase O, formate hydrogenlyase, methylviologen-dependent formate dehydrogenase, molybdenum-containing formate dehydrogenase H

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.98 With other, known, physiological acceptors

                1.17.98.4 formate dehydrogenase (hydrogenase)

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Results	in table
2	Activating Compound
629	AA Sequence
2	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
2	Expression
1	General Information
2	General Stability
19	Inhibitors
2	Ki Value [mM]
5	KM Value [mM]
2	Localization
23	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
31	Organism
4	Oxidation Stability
3	Pathway
1	PDB ID
6	pH Optimum
2	pH Range
7	pH Stability
2	Protein Variants
6	Purification (Commentary)
1	Reaction
27	Reference
3	Source Tissue
3	Specific Activity [micromol/min/mg]
32	Substrates and Products (Substrate)
6	Subunits
28	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.17.98.4 - formate dehydrogenase (hydrogenase)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystals diffract to 2.6 A resolution and belong to a space group of P4(1)2(1)2 or P4(3)2(1)2 with unit cell dimensions a = b = 146.1 A and c = 82.7 A. There is one monomer of FDH per crystallographic asymmetric unit. Similar diffraction quality crystals of oxidized FDH can be obtained by oxidation of crystals of formate-reduced enzyme with benzyl viologen. Mo(IV)- and the reduced FeS cluster containing form of the enzyme was crystallized and this can be converted into Mo(VI)- and oxidized FeS cluster form upon oxidation

Escherichia coli

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698704

reinterpretation of the crystal structure

Escherichia coli

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674932