1.14.19.59: tryptophan 6-halogenase

This is an abbreviated version!
For detailed information about tryptophan 6-halogenase, go to the full flat file.

Word Map on EC 1.14.19.59

1.14.19.59

halogenases

flavin-dependent

albogriseolus

biocatalysts

indole

flavin

bromination

regioselectivity

bromide

halide

non-ribosomal

pet28a

7-halogenase

toxytricini

biocatalytic

regiospecific

analysis

Reaction

+ 2 H2O

Synonyms

sttH, Thal, ThdH

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.59 tryptophan 6-halogenase

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Results	in table
2	AA Sequence
1	Application
4	Cloned(Commentary)
2	Cofactor
4	General Information
4	kcat/KM [mM/s]
8	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
10	Organism
1	pH Optimum
1	pH Range
3	Protein Variants
1	Purification (Commentary)
4	Reaction
8	Reference
25	Substrates and Products (Substrate)
3	Subunits
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Temperature Range [°C]
2	Temperature Stability [°C]
5	Turnover Number [1/s]

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Reference on EC 1.14.19.59 - tryptophan 6-halogenase

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727223

Zeng, J.; Zhan, J.

Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini

Biotechnol. Lett.

1607-1613

2011

Streptomyces toxytricini (E9P162), Streptomyces toxytricini

21424165

744028

Schnepel, C.; Minges, H.; Frese, M.; Sewald, N.

A high-throughput fluorescence assay to determine the activity of tryptophan halogenases

Angew. Chem. Int. Ed. Engl.

14159-14163

2016

Streptomyces albogriseolus (A1E280)

27618794

744198

Seibold, C.; Schnerr, H.; Rumpf, J.; Kunzendorf, A.; Hatscher, C.; Wage, T.; Ernyei, A.; Dong, C.; Naismith, J.; van Pee, K.

A flavin-dependent tryptophan 6-halogenase and its use in modification of pyrrolnitrin biosynthesis

Biocatal. Biotransform.

401-408

2006

Streptomyces albogriseolus (A1E280), Streptomyces albogriseolus MJ286-76F7 (A1E280)

744565

Fraebel, S.; Krischke, M.; Staniek, A.; Warzecha, H.

Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes

Biotechnol. J.

1586-1594

2016

Streptomyces toxytricini (E9P162)

27687297

744696

Milbredt, D.; Patallo, E.P.; van Pee, K.H.

A tryptophan 6-halogenase and an amidotransferase are involved in thienodolin biosynthesis

ChemBioChem

1011-1020

2014

Streptomyces albogriseolus (A1E280), Streptomyces albogriseolus, Streptomyces albogriseolus MJ286-76F7 (A1E280)

24692213

744705

Shepherd, S.A.; Menon, B.R.; Fisk, H.; Struck, A.W.; Levy, C.; Leys, D.; Micklefield, J.

A structure-guided switch in the regioselectivity of a tryptophan halogenase

ChemBioChem

821-824

2016

Streptomyces toxytricini (E9P162)

26840773