1.14.19.59: tryptophan 6-halogenase
This is an abbreviated version!
For detailed information about tryptophan 6-halogenase, go to the full flat file.
Word Map on EC 1.14.19.59
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1.14.19.59
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halogenases
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flavin-dependent
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albogriseolus
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biocatalysts
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indole
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flavin
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bromination
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regioselectivity
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bromide
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halide
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non-ribosomal
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pet28a
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7-halogenase
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toxytricini
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biocatalytic
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regiospecific
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analysis
- 1.14.19.59
- halogenases
-
flavin-dependent
- albogriseolus
-
biocatalysts
- indole
- flavin
-
bromination
-
regioselectivity
- bromide
- halide
-
non-ribosomal
-
pet28a
-
7-halogenase
- toxytricini
-
biocatalytic
-
regiospecific
- analysis
Reaction
Synonyms
sttH, Thal, ThdH
ECTree
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General Information
General Information on EC 1.14.19.59 - tryptophan 6-halogenase
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physiological function
the first step in thienodolin biosynthesis is catalyzed by a tryptophan 6-halogenase, and the last step is the formation of a carboxylic amide group catalyzed by an amidotransferase. Gene ThdH encodes tryptophan 6-halogenase, which catalyzes the regioselective chlorination of tryptophan to 6-chlorotryptophan. This flavin-dependent halogenase requires the participation of a flavin reductase, which is encoded by thdF. A gene deletion mutant of tryptophan 6-halogenase ThdH is not able to produce thienedolin
physiological function
transformation of the pyrrolnitrin producer Pseudomonas chlororaphis ACN with a plasmid containing the tryptophan 6-halogenase gene leads to the formation of the aminopyrrolnitrin derivative 3-(2'-amino-4'-chlorophenyl)pyrrole
physiological function
Streptomyces albogriseolus MJ286-76F7
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transformation of the pyrrolnitrin producer Pseudomonas chlororaphis ACN with a plasmid containing the tryptophan 6-halogenase gene leads to the formation of the aminopyrrolnitrin derivative 3-(2'-amino-4'-chlorophenyl)pyrrole
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physiological function
Streptomyces albogriseolus MJ286-76F7
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the first step in thienodolin biosynthesis is catalyzed by a tryptophan 6-halogenase, and the last step is the formation of a carboxylic amide group catalyzed by an amidotransferase. Gene ThdH encodes tryptophan 6-halogenase, which catalyzes the regioselective chlorination of tryptophan to 6-chlorotryptophan. This flavin-dependent halogenase requires the participation of a flavin reductase, which is encoded by thdF. A gene deletion mutant of tryptophan 6-halogenase ThdH is not able to produce thienedolin
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