2.4.1.214: glycoprotein 3-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about glycoprotein 3-alpha-L-fucosyltransferase, go to the full flat file.

Reaction

Synonyms

alpha 1,3-fucosyltransferase VI, alpha(1,3)-fucosyltransferase VII, alpha(1,3)-fucosyltransferase-IV, alpha(1,3)-fucosyltransferase-VII, alpha(1,3)fucosyltransferase, alpha-1,3-fucosyltransferase-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 10, alpha1,3-fucosyltransferase 7, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase IX, alpha1,3FTs, alpha1-3 fucosyltransferase-VII, alpha3-fucosyltransferase, alpha3-FucT VII, AtFUT11, CEFT-1, CEFT-2, CEFT-3, CEFT-4, CEFT-5, CEFT3, core alpha-(1,3)-fucosyltransferase, core alpha1,3-fucosyltransferase, Fuc-T C3, Fuc-TVII, fucosyltransferase A, fucosyltransferase VII, FucT, FucT 115, FucT 45, FucT VI, FucT VII, FucT-IV, FucT-VII, FucT1, FucTA, FucTB, FucTC, FUT-1, FUT-6, FUT10, FUT11, FUT7, Fut9, GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuca1-6GlcNAc)-Asn-peptide) alpha1-3-fucosyltransferase, GDP-L-fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase, LOC107797347, LOC107830046, NM_001324945, XM_016620229, XM_016657530

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase

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Results	in table
4	Activating Compound
110	AA Sequence
3	Application
1	CAS Registry Number
25	Cloned(Commentary)
1	Crystallization (Commentary)
199	Disease/ Diagnostics
2	Expression
5	General Information
42	Inhibitors
2	kcat/KM [mM/s]
1	Ki Value [mM]
60	KM Value [mM]
4	Localization
32	Metals/Ions
15	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
44	Organism
3	Pathway
12	pH Optimum
4	pH Range
5	Posttranslational Modification
45	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
40	Reference
46	Source Tissue
24	Specific Activity [micromol/min/mg]
94	Substrates and Products (Substrate)
11	Subunits
91	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.214 - glycoprotein 3-alpha-L-fucosyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R

GDP + Galbeta1-4[Fucalpha1-3]GlcNAc-R

Homo sapiens

-

-

661836

-

-

ir

GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc

GDP + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(Fucalpha(1->3))GlcNAc

Arabidopsis thaliana

Q9C8W3

-

722352

-

-

?

GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc

GDP + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc

Caenorhabditis elegans

G5EDR5

-

722352

-

-

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

7 entries

additional information

?

-

13 entries

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Apis mellifera

-

-

349719

-

349719

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Arabidopsis thaliana

-

-

349715

-

349715

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Cricetulus griseus

-

-

349721

-

349721

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Drosophila melanogaster

-

-

349716

-

349716

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Homo sapiens

-

-

349720

-

349720

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Lymnaea stagnalis

-

-

349718

-

349718

?

GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine

GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine

Vigna radiata

-

-

349717

-

349717

?

additional information

?

-

Arabidopsis thaliana

-

the core alpha1-3-fucosyltransferases are involved in the synthesis of glycans specific to plants and invertebrates which are known to be immunogenic and allergenic

349715

-

-

?

additional information

?

-

Homo sapiens

-

alpha1,3-fucosylation by FucT-VII is a step in the biosynthesis of Lewis X antigen, FucT-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1, phosphorylation of the Rb protein is involved, signaling pathway overview

661454

-

-

?

additional information

?

-

Homo sapiens

-

FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability

662441

-

-

?

additional information

?

-

Homo sapiens

-

FucT-VII is essential for biosynthesis of selectin binding ligands in T-cells, H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells via the Raf-MEK-ERK pathway, but induction of FucT-VII requires the concomitant activation of at least 3 different signaling pathways, overview

662265

-

-

?

additional information

?

-

Homo sapiens

-

sialyl Lewis X biosynthesis is mediated by alpha1-3 fucosyltransferase-VIIS, the enzyme is essential for biosynthesis of P- and E-selectin binding ligands in T-cells

660887

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is essential for biosynthesis of selectin binding ligands in T-cells

662566

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is responsible for the generation of functional P- and E-selectin ligands

662725

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme synthesizes functional selectin ligands on the surface of leukocytes

661836

-

-

?

additional information

?

-

Lymnaea stagnalis

-

the enzyme functions in the synthesis of core alpha1-3-fucosylated complex-type glycans

349718

-

-

?

additional information

?

-

Mus musculus

-

Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes

662545

-

-

?

additional information

?

-

Mus musculus

-

FucT-IV E- and P-selectin ligand precursors to give mature E- and P-selectin ligands, 3-alpha-fucosylates FucT-VII 3-alpha-fucosylates P-selectin ligand precursors to give mature P-selectin ligands that are essential for control of frequency of and all interaction related to leukocyte rolling, overview, FucT-IV and FucT-VII show overlapping activities in the immunosurveillance of the skin

661857

-

-

?

additional information

?

-

Mus musculus

-

the enzyme performs Lewis X carbohydrate structure synthesis on oligosaccharides, polylactosamine chains, and glycolipids in the brain with high alpha1,3-fucosyltransferase activity

661837

-

-

?

additional information

?

-

Schistosoma sp.

-

the native enzyme accepts core alpha1,6-fucosylated glycans as substrates for core alpha1,3-fucosylation prior Lewis-type fucosylation, strict order of fucosylation events, overview

661843

-

-

?