2.3.1.281: 5-hydroxydodecatetraenal polyketide synthase

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For detailed information about 5-hydroxydodecatetraenal polyketide synthase, go to the full flat file.

Reaction

6 malonyl-CoA + 5 NADPH +

Synonyms

cpkAB

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.281 5-hydroxydodecatetraenal polyketide synthase

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1	AA Sequence
1	Cloned(Commentary)
2	Expression
4	General Information
8	Organism
1	Pathway
1	Reaction
4	Reference
6	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.281 - 5-hydroxydodecatetraenal polyketide synthase

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SYSTEMATIC NAME

IUBMB Comments

malonyl-CoA:malonyl-CoA malonyltransferase ((2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal-forming)

This polyketide synthase enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), catalyses the first reaction in the biosynthesis of coelimycin P1. The enzyme is made of three proteins which together comprise six modules that contain a total of 28 domains. An NADH-dependent terminal reductase domain at the C-terminus of the enzyme catalyses the reductive release of the product.