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2.3.1.281: 5-hydroxydodecatetraenal polyketide synthase

This is an abbreviated version!
For detailed information about 5-hydroxydodecatetraenal polyketide synthase, go to the full flat file.

Reaction

6 malonyl-CoA + 5 NADPH +

NADH
+ 6 H+ =
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal
+ 6 CoA + 5 NADP+ +
NAD+
+ 6 CO2 + 4 H2O

Synonyms

cpkAB

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.281 5-hydroxydodecatetraenal polyketide synthase

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Resultsin table
1AA Sequence
1Cloned(Commentary)
2Expression
4General Information
8Organism
1Pathway
1Reaction
4Reference
6Substrates and Products (Substrate)
1Synonyms
1Systematic Name

Reference

Reference on EC 2.3.1.281 - 5-hydroxydodecatetraenal polyketide synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pawlik, K.; Kotowska, M.; Chater, K.; Kuczek, K.; Takano, E.
A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2)
Arch. Microbiol.
187
87-99
2007
Streptomyces coelicolor (Q9L8J0), Streptomyces coelicolor A3(2) (Q9L8J0)
Manually annotated by BRENDA team
Awodi, U.; Ronan, J.; Masschelein, J.; De Los Santos, E.; Challis, G.
Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis
Chem. Sci.
8
411-415
2016
Streptomyces coelicolor, Streptomyces coelicolor M145
Manually annotated by BRENDA team