2.1.1.320: type II protein arginine methyltransferase
This is an abbreviated version!
For detailed information about type II protein arginine methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.320
-
2.1.1.320
-
histone
-
methyltransferases
-
chromatin
-
prmts
-
dimethylarginine
-
tumorigenesis
-
h4r3me2s
-
monomethylation
-
spliceosomal
-
mep50
-
methylosome
-
ribonucleoproteins
-
non-histone
-
pre-mrna
-
snrnps
-
picln
-
monomethylarginine
-
methylthioadenosine
-
tudor
-
menin
-
protein-arginine
-
medicine
- 2.1.1.320
- histone
- methyltransferases
- chromatin
-
prmts
- dimethylarginine
- tumorigenesis
-
h4r3me2s
-
monomethylation
-
spliceosomal
- mep50
-
methylosome
- ribonucleoproteins
-
non-histone
- pre-mrna
-
snrnps
-
picln
-
monomethylarginine
- methylthioadenosine
-
tudor
-
menin
- protein-arginine
- medicine
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1
ECTree
Advanced search results
IC50 Value
IC50 Value on EC 2.1.1.320 - type II protein arginine methyltransferase
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0.0000079
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(E)-2-(quinolin-7-yl)ethenyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(S)-(3,4-difluorophenyl)(hydroxy)methyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000026
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[(quinolin-7-yl)oxy]methyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000079
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(2-[2-[(cyclopropylmethyl)amino]quinolin-7-yl]ethyl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000002
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2,3-dimethylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000025
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2-aminoquinolin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000008
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000016
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-chloro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000032
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-fluoro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000063
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(quinolin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1S,2R,3R,5R)-3-[(R)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000013
(1S,2R,3S,5R)-3-[2-(2-amino-3-bromoquinolin-7-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000000501
(1S,2R,3S,5R)-3-[2-(6-aminopyridin-3-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000004
(1S,2R,3S,5R)-3-[4-(6-aminopyridin-2-yl)butyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000026
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(4-chloro-3-fluorophenyl)sulfanyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000126
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(quinolin-7-yl)methoxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[(5-fluoro-6-methoxy-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[(6-bromo-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethoxy)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-4-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(2R,3S,4R,5R)-2-[(S)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000006
(4Z)-7-[(5R)-5-amino-5-(4-chlorophenyl)-5-deoxy-beta-D-ribofuranosyl]-4-hydrazinylidene-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000003
(5R)-5'-C-(3,4-difluorophenyl)adenosine
Homo sapiens
pH and temperature not specified in the publication
0.000517
1-(6-bromo-9-ethyl-9H-carbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine
Homo sapiens
pH and temperature not specified in the publication
0.000116
1-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-3-ethynyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0028
2-([[2-(benzyloxy)-1,4-dihydronaphthalen-1-yl]methyl]amino)-1-phenylethan-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.04587
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-fluorophenyl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06295
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[3-(trifluoromethoxy)phenyl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06987
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[4-(trifluoromethyl)pyrimidin-2-yl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.000009
7-[(5R)-5-amino-5-deoxy-5-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000003
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000002
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000001
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.00000002
7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000017
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000043
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000095 - 0.000026
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
0.0000158
7-[5-O-(quinolin-7-yl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000001
8-[[(1S,2S,3S,4R)-2,3-dihydroxy-4-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentyl]oxy]-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile
Homo sapiens
pH and temperature not specified in the publication
0.000035
dehydrosinefungin
Homo sapiens
pH and temperature not specified in the publication
0.06
methyl 2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.00033
methyl 2-[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.03162
methyl 2-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.08789
methyl 2-[4-(3,4-dihydroisoquinolin-2(1H)-yl)butanamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.07254
N'-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanoyl]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.02555
N-(2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.05195
N-(3-acetylphenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.00271
N-(3-bromo-2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.01812
N-(3-bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.04213
N-(3-chlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.000047
N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000022
N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-[(oxetan-3-yl)amino]pyrimidine-4-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00056
S-adenosyl-L-homocysteine
Homo sapiens
pH and temperature not specified in the publication
0.0000095
Homo sapiens
pH and temperature not specified in the publication