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2.1.1.320: type II protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type II protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.320

Reaction

2 S-adenosyl-L-methionine +

[protein]-L-arginine
= 2 S-adenosyl-L-homocysteine +
[protein]-Nomega,Nomega'-dimethyl-L-arginine

Synonyms

At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.320 type II protein arginine methyltransferase

IC50 Value

IC50 Value on EC 2.1.1.320 - type II protein arginine methyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000079
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(E)-2-(quinolin-7-yl)ethenyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(S)-(3,4-difluorophenyl)(hydroxy)methyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000026
(1R,2S,3R,5R)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[(quinolin-7-yl)oxy]methyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000079
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(2-[2-[(cyclopropylmethyl)amino]quinolin-7-yl]ethyl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000002
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2,3-dimethylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000025
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(2-aminoquinolin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000008
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000016
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-chloro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000032
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(6-fluoro-3-methylimidazo[1,2-a]pyridin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000063
(1R,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[2-(quinolin-7-yl)ethyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1S,2R,3R,5R)-3-[(R)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.00000013
(1S,2R,3S,5R)-3-[2-(2-amino-3-bromoquinolin-7-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000000501
(1S,2R,3S,5R)-3-[2-(6-aminopyridin-3-yl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000004
(1S,2R,3S,5R)-3-[4-(6-aminopyridin-2-yl)butyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000026
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(4-chloro-3-fluorophenyl)sulfanyl]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000126
(1S,2S,3R,5S)-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(quinolin-7-yl)methoxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000002
(1S,2S,3R,5S)-3-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[[6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[(5-fluoro-6-methoxy-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[(6-bromo-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethoxy)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-4-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
pH and temperature not specified in the publication
0.000001
(2R,3S,4R,5R)-2-[(S)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000006
(4Z)-7-[(5R)-5-amino-5-(4-chlorophenyl)-5-deoxy-beta-D-ribofuranosyl]-4-hydrazinylidene-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000003
(5R)-5'-C-(3,4-difluorophenyl)adenosine
Homo sapiens
pH and temperature not specified in the publication
0.000517
1-(6-bromo-9-ethyl-9H-carbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine
Homo sapiens
pH and temperature not specified in the publication
0.000116
1-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-3-ethynyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0028
2-([[2-(benzyloxy)-1,4-dihydronaphthalen-1-yl]methyl]amino)-1-phenylethan-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.04587
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-fluorophenyl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06295
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[3-(trifluoromethoxy)phenyl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06987
3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[4-(trifluoromethyl)pyrimidin-2-yl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.000009
7-[(5R)-5-amino-5-deoxy-5-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000003
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
pH and temperature not specified in the publication
0.000002
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000001
7-[(5R)-5-C-(3,4-difluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.00000002
7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000017
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-5-ethynyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000043
7-[(5R)-5-C-(4-chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000095 - 0.000026
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
0.0000158
7-[5-O-(quinolin-7-yl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000001
8-[[(1S,2S,3S,4R)-2,3-dihydroxy-4-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentyl]oxy]-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile
Homo sapiens
pH and temperature not specified in the publication
0.000035
dehydrosinefungin
Homo sapiens
pH and temperature not specified in the publication
0.06
methyl 2-[2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.00033
methyl 2-[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.03162
methyl 2-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.08789
methyl 2-[4-(3,4-dihydroisoquinolin-2(1H)-yl)butanamido]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.07254
N'-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propanoyl]benzohydrazide
Homo sapiens
pH and temperature not specified in the publication
0.02555
N-(2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.05195
N-(3-acetylphenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.00271
N-(3-bromo-2-cyanophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.01812
N-(3-bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.04213
N-(3-chlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.000047
N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000022
N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-[(oxetan-3-yl)amino]pyrimidine-4-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00056
S-adenosyl-L-homocysteine
Homo sapiens
pH and temperature not specified in the publication