2.1.1.28: phenylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phenylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.28
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2.1.1.28
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catecholamine
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medulla
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hydroxylase
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adrenergic
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dopamine
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chromaffin
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beta-hydroxylase
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glucocorticoid
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sympathetic
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rostrally
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catecholaminergic
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noradrenergic
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innervation
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ventrolateral
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hypothalamic
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corticosterone
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catecholamine-synthesizing
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oblongata
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dopamine-beta-hydroxylase
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pnmt-immunoreactive
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perikarya
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tractus
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adrenomedullary
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proenkephalin
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dorsomedial
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sympathoadrenal
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intermediolateral
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alpha2-adrenoceptor
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1,2,3,4-tetrahydroisoquinoline
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coeruleus
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phenylethanolamine-n-methyltransferase
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postrema
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pnmt-ir
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medicine
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bulbospinal
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normetanephrine
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solitarii
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analysis
- 2.1.1.28
- catecholamine
- medulla
- hydroxylase
-
adrenergic
- dopamine
-
chromaffin
- beta-hydroxylase
- glucocorticoid
-
sympathetic
-
rostrally
-
catecholaminergic
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noradrenergic
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innervation
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ventrolateral
- hypothalamic
- corticosterone
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catecholamine-synthesizing
- oblongata
- dopamine-beta-hydroxylase
-
pnmt-immunoreactive
- perikarya
-
tractus
-
adrenomedullary
- proenkephalin
-
dorsomedial
-
sympathoadrenal
-
intermediolateral
-
alpha2-adrenoceptor
- 1,2,3,4-tetrahydroisoquinoline
-
coeruleus
-
phenylethanolamine-n-methyltransferase
-
postrema
-
pnmt-ir
- medicine
-
bulbospinal
- normetanephrine
-
solitarii
- analysis
Reaction
Synonyms
hPNMT, methyltransferase, noradrenaline N-, NMT, noradrenalin methyltransferase, noradrenalin N-methyltransferase, noradrenaline N-methyltransferase, norepinephrin N-methyltransferase, norepinephrine methyltransferase, norepinephrine N-methyltransferase, phenethanolamine methyltransferase, phenethanolamine N-methyltransferase, PNMT
ECTree
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Organism
Organism on EC 2.1.1.28 - phenylethanolamine N-methyltransferase
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639430, 639431, 639433, 639437, 639438, 639442, 639443, 639447, 639448, 639455, 639456, 639457, 639458
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21 male and 1 female patient at 0-12 years after heart transplantation, mean age 45.7 years: During the first years after heart transplantation, phenylethanolamine N-methyltransferase mRNA levels are relatively high compared with later years. There is a correlation of phenylethanolamine N-methyltransferase mRNA with years elapsed form heart transplantation (r = -0.56). There is a negative linear correlation between phenylethanolamine N-methyltransferase mRNA and the low frequency band of the power spectrum (r = - 0.47).
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immunohistochemical analysis in normal human medulla shows a expression of phenylethanolamine N-methyltransferase localized to the cytoplasm. All tyrosine hydroxylase-positive cells contain phenylethanolamine N-methyltransferase. All normal human chromaffin cells also strongly express noradrenaline transporter, which is always colocalized with phenylethanolamine N-methyltransferase. Double-labeling experiments on phaeochromocytoma tissue reveals, that the expression of phenylethanolamine N-methyltransferase is variable, ranging from strong to weak to absent. The immunohistochemical detection of phenylethanolamine N-methyltransferase correlates with the presence of adrenaline in all but one sample (but the intensitiy levels do not correlate). In human phaeochromocytomas the expression of the noradrenaline transporter is not consistently co-localized with phenylethanolamine N-methyltransferase.
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the phenylethanolamine N-methyltransferase inhibitory potency of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline is lower than the of other 1,2,3,4-tetrahydroisoquinolines, some of them show good selectivity due to their extremely low alpha2-adrenoceptor affinity
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male corticotropin-releasing hormone knockout mice (C57B1/129SV, 20-25 g, approximately 12 weeks old) and wild type mice
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mouse pheochromocytoma cell lines 862L and 10/9CRC1 from tumors arising in separate mice with a heterozygous knockout of the neurofibromatosis gene Nf1
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Wistar rats, 6-12 weeks, either sex. In the immunohistochemistry experiment phenylethanolamine N-methyltransferase demonstrate strong staining in the majority of cells, representing the adrenergic cell population.
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