2.1.1.261: 4-dimethylallyltryptophan N-methyltransferase

This is an abbreviated version!
For detailed information about 4-dimethylallyltryptophan N-methyltransferase, go to the full flat file.

Reaction

Synonyms

easF, fgaMT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.261 4-dimethylallyltryptophan N-methyltransferase

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Results	in table
10	AA Sequence
1	Application
3	Cloned(Commentary)
3	Cofactor
3	General Information
1	Inhibitors
2	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
3	Pathway
1	pH Optimum
1	Protein Variants
1	Purification (Commentary)
1	Reaction
4	Reference
9	Substrates and Products (Substrate)
2	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 2.1.1.261 - 4-dimethylallyltryptophan N-methyltransferase

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additional information

Aspergillus fumigatus

an engineered strain named Aspergillus nidulans WFC, expressing ergot alkaloid synthesis genes dmaW, easF, and easC, produces the established intermediate N-methyl-4-dimethylallyltryptophan, as well as an ergot alkaloid, that is characterized as ergotryptamine, it differs from N-methyl-4-dimethylallyltryptophan by the loss of the carboxyl group, addition of a hydroxyl group, and shift in position of a carbon-carbon double bond, by mass spectrometry, labeling, and NMR. Feeding studies with Aspergillus mutants do not show ergotryptamine turnover, suggesting it is a pathway byproduct as opposed to an authentic intermediate

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