1.14.19.70: mycocyclosin synthase
This is an abbreviated version!
For detailed information about mycocyclosin synthase, go to the full flat file.
Word Map on EC 1.14.19.70
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1.14.19.70
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tuberculosis
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heme
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azole
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antimycobacterial
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clotrimazole
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triazole
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antituberculosis
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fragment-based
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econazole
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fluconazole
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medicine
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isoniazid
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pharmacology
- 1.14.19.70
- tuberculosis
- heme
- azole
-
antimycobacterial
- clotrimazole
- triazole
-
antituberculosis
-
fragment-based
- econazole
- fluconazole
- medicine
- isoniazid
- pharmacology
Reaction
+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + = + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
Synonyms
CYP121, EC 1.14.21.9, rv2276
ECTree
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Inhibitors
Inhibitors on EC 1.14.19.70 - mycocyclosin synthase
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not inhibited by cyclo(L-Tyr-L-Leu) and cyclo(L-Tyr-L-Met)
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additional information
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not inhibited by cyclo(L-Tyr-L-Leu) and cyclo(L-Tyr-L-Met)
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additional information
the cyclo-dipeptide substrates of the essential Mycobacterium tuberculosis enzyme CYP121 are deconstructed into their component fragments and screened against the enzyme
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additional information
biophysical screening procedure employing a focused library of privileged scaffolds, which ultimately lead to the discovery of novel CYP121 inhibitors
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additional information
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biophysical screening procedure employing a focused library of privileged scaffolds, which ultimately lead to the discovery of novel CYP121 inhibitors
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