1.14.16.4: tryptophan 5-monooxygenase
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For detailed information about tryptophan 5-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.4
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1.14.16.4
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serotonin
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serotonergic
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raphe
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5-hydroxytryptamine
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monoamine
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dorsal
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dopamine
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neurotransmitter
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hippocampus
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antidepressant
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reuptake
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5-hydroxytryptophan
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anxiety
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psychiatric
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midbrain
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striatum
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hypothalamus
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neurochemical
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5-hydroxyindoleacetic
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mood
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enterochromaffin
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neurotransmission
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5-hiaa
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p-chlorophenylalanine
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fluoxetine
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pineal
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brainstem
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alpha-methyl-p-tyrosine
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monoaminergic
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5,7-dihydroxytryptamine
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analysis
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methamphetamine
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autoreceptors
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slc6a4
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immobility
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pargyline
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n-acetylserotonin
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neostriatal
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5-httlpr
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medicine
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citalopram
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antidepressant-like
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carcinoid
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biopterins
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impulsivity
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oxidase-a
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tetrahydropterins
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fenfluramine
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impulsive
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8-oh-dpat
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5-hydroxyindole
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drug development
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3,4-methylenedioxymethamphetamine
- 1.14.16.4
- serotonin
-
serotonergic
-
raphe
- 5-hydroxytryptamine
-
monoamine
-
dorsal
- dopamine
-
neurotransmitter
- hippocampus
-
antidepressant
-
reuptake
- 5-hydroxytryptophan
-
anxiety
-
psychiatric
- midbrain
- striatum
- hypothalamus
-
neurochemical
-
5-hydroxyindoleacetic
-
mood
-
enterochromaffin
-
neurotransmission
-
5-hiaa
- p-chlorophenylalanine
- fluoxetine
-
pineal
- brainstem
- alpha-methyl-p-tyrosine
-
monoaminergic
-
5,7-dihydroxytryptamine
- analysis
- methamphetamine
-
autoreceptors
-
slc6a4
-
immobility
- pargyline
- n-acetylserotonin
- neostriatal
-
5-httlpr
- medicine
- citalopram
-
antidepressant-like
- carcinoid
- biopterins
-
impulsivity
-
oxidase-a
- tetrahydropterins
- fenfluramine
-
impulsive
-
8-oh-dpat
- 5-hydroxyindole
- drug development
- 3,4-methylenedioxymethamphetamine
Reaction
Synonyms
hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase
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Source Tissue
Source Tissue on EC 1.14.16.4 - tryptophan 5-monooxygenase
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TPH expression pattern during development, TPH expression was found from tailbud stage in the precursor cells of the visceral ganglion and in the tail
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in vivo predominantly localized to normal and malignant melanocytes
main expression of gene TPH at commissure axonal connections in the ventral nerve cords
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human small cell lung carcinoma cell line, SHP-77 cells preferentially express TPH1 over TPH2 mRNA
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ventral horn, enzyme expression in muscle after exercise-induced fatigue and control muscle, overview
additional information
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immunohistochemic analysis for TPH-like reactivity, neuronal distribution, overview
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immunohistochemic analysis for TPH-like reactivity, neuronal distribution, overview
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immunohistochemic analysis for TPH-like reactivity, neuronal distribution, overview
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activity in hypothalamus and midbrain-medulla regions, no activity in cerebellum or cortex
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immunohistochemic analysis for TPH-like reactivity, neuronal distribution, overview
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immunohistochemic analysis for TPH-like reactivity, neuronal distribution, overview
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immunohistochemic analysis for TPH-like reactivity, neuronal distribution, overview
dorsal and median raphe nuclei, in the dorsal raphe nucleus there are more serotonin neurons and more neuronal TPH2 expression postmortem in depressed suicides. Depressed suicides have 26.5% more TPH2 grain density per neuron in the DRN compared with matched controls
TPH1 is expressed predominantly during the late developmental stage in the brain
high expression of TPH-1 throughout the brain but is greatest in the hypothalamic region
high expression of TPH-2 throughout the brain but it is greatest in the hypothalamic region
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the selective serotonin reuptake inhibitor citalopram has no effect in mice strain that exhibit a reduced 5-hydroxy-L-tryptophan synthesis due to a mutatation in the tryptophan hydroxylase 2
circadian expression of TPH in dorsal and median raphe in correlation to glucocorticoid fluctuations, e.g. corticosterone, expression pattern, overview
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dorsal raphe nucleus, expression analysis and enzyme levels of TPH2, quantitative immunoautoradiography and in situ hybridization histochemistry, overview, activity occurs also in striatum, nucleus accumbens and cingulate cortex
in raphe nuclei, in lateral hypothalamic nuclei and in pineal body
TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus and in the brainstem containing the rest of the raphe complex
TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus and in the brainstem containing the rest of the raphe complex
TPHexpressing neurons form two clusters in the anterior central nervous system at the level of the visceral ganglion
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enzyme distribution between optic lobe and protocerebrum, dorsal protocerebrum, deutocerebrum, and subesophageal ganglion, overview
additional information
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enzyme distribution between optic lobe and protocerebrum, dorsal protocerebrum, deutocerebrum, and subesophageal ganglion, overview
additional information
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enzyme distribution between optic lobe and protocerebrum, dorsal protocerebrum, deutocerebrum, and subesophageal ganglion, overview
additional information
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enzyme distribution between optic lobe and protocerebrum, dorsal protocerebrum, deutocerebrum, and subesophageal ganglion, overview
additional information
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enzyme distribution between optic lobe and protocerebrum, dorsal protocerebrum, deutocerebrum, and subesophageal ganglion, overview
additional information
expression pattern of TPH in whole animals, in situ hybridization, overview
additional information
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expression pattern of TPH in whole animals, in situ hybridization, overview
additional information
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enzyme distribution between optic lobe and protocerebrum, dorsal protocerebrum, deutocerebrum, and subesophageal ganglion, overview
additional information
analysis of TPH2 expression in brain tissues, overview
additional information
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TPH1 is found in the periphery and pineal gland whereas TPH2 is expressed specifically in the central nervous system
additional information
TPH1 mRNA is mainly expressed in the pineal gland and the periphery
additional information
TPH1 mRNA is mainly expressed in the pineal gland and the periphery
additional information
TPH2 mRNA is preferentially expressed in the brain and in the peripheral myenteric neurons in the gut
additional information
TPH2 mRNA is preferentially expressed in the brain and in the peripheral myenteric neurons in the gut
additional information
TPH-1 is absent from heart, intestine kidney, muscle, and liver
additional information
TPH-1 is absent from heart, intestine kidney, muscle, and liver
additional information
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TPH-1 is absent from heart, intestine kidney, muscle, and liver
additional information
TPH-2 is absent from intestine and muscle
additional information
TPH-2 is absent from intestine and muscle
additional information
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expression pattern of tryptophan hydroxylase in senescence-accelerated prone mouse 6, overview
additional information
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tissue distribution and expression levels of TPH2 and TPH1 in normoxic and hypoxic wild-type and mutant mice, overview
additional information
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TPH1 is primarily expressed in the pineal gland and non-neuronal tissues, such as enterochromaffin cells of the gastrointestinal tract. TPH2, the dominant isozyme in the brain, is expressed exclusively in neuronal cells, such as dorsal raphe or myenteric plexus cells
additional information
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analysis of TPH2 expression in brain tissues, overview
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additional information
analysis of TPH2 expression in brain tissues, overview
additional information
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olfactory bulbectomized rats, i.e. OBX rats, with olfactory bulbs removed by suction, no significant difference in the effects on TPH immunoreactivity in the median raphe of OBX rats between vehicle- and antidepressants-treated animals