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1.14.14.14: aromatase

This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.

Word Map on EC 1.14.14.14

Reaction

19-hydroxyandrost-4-ene-3,17-dione
+
O2
 +
[reduced NADPH-hemoprotein reductase]
=
19-oxo-androst-4-ene-3,17-dione
 + 2 H2O +
[oxidized NADPH-hemoprotein reductase]

Synonyms

AROM, Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.14 aromatase

Expression

Expression on EC 1.14.14.14 - aromatase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Cyp19a expression is significantly lower at 52 days post-hatch at the male-producing temperature (19°C) and increases to similar levels as treatments at 13°C or 16°C at 66 days post-hatch. Expression levels later in juvenile development (66–191 days post-hatch) largely decrease with fish size
CYP19A1 mRNA levels and aromatase activity in villous cytotrophoblast cells reach a maximum after about 48 h of culture
dexamethasone (100 nM) and vascular endothelial growth factor (5 ng/ml) decrease CYP19A1 mRNA levels, while having no effect on aromatase activity
expression is upregulated upon treatment with benzophenone-2, 4-phenylphenol, bisphenol A, bisphenol S, and n-butylparaben. Cells treated with DDT, methoxychlor, benzophenone-2,4-phenylphenol, bisphenol A, bisphenol S, and n-butylparaben, display significantly increased aromatase enzyme activity
forskolin (10 mM) and myristate acetate (1 mM) increases CYP19A1 mRNA levels by 1.8- and 1.6fold, respectively, as well as inducing aromatase catalytic activity
gene is expressed highly in the resting phase and gives the highest transcript abundance in the preparatory phase. Human chorionic gonadotropin administration stimulates the expression
hypothalamic aromatase levels increase two times during annual gonadal cycle, once in a fully gravid fish and then in a reproductively quiescent fish
-
hypoxia exposure for 4 weeks or treatment with N-ethylmaleimide causes significant decreases in hypothalamic AROM activity, brain AROM mRNA and protein expressions. Treatments with Nomega-nitro-L-arginine methyl ester or vitamin-E prevent the downregulation of hypothalamic AROM activity and mRNA levels in hypoxic fish
phosphodiesterase type-5 inhibitor tadalafil inhibits aromatase mRNA and protein expression leading to an increase in testosterone levels in the supernatants