1.14.14.14: aromatase
This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.
Word Map on EC 1.14.14.14
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1.14.14.14
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estrogen
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women
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androgen
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steroid
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postmenopausal
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ovarian
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tamoxifen
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ovary
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progesterone
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letrozole
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granulosa
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follicle
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gonad
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anastrozole
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receptor-positive
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fsh
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steroidogenic
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exemestane
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androstenedione
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gonadotropin
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steroidogenesis
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endometrial
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lutein
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follicular
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testicular
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antiestrogens
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fulvestrant
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er-positive
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nonsteroidal
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endometriosis
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neoadjuvant
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preoptic
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third-generation
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hormone-dependent
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follicle-stimulating
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gnrh
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estrogen-dependent
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oestradiol
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dihydrotestosterone
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premenopausal
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mastectomy
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arthralgia
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17beta-hydroxysteroid
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everolimus
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5alpha-reductase
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cyp17a1
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raloxifene
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medicine
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virilization
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progestin
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her2-negative
- 1.14.14.14
- estrogen
- women
- androgen
- steroid
-
postmenopausal
- ovarian
- tamoxifen
- ovary
- progesterone
- letrozole
-
granulosa
- follicle
- gonad
- anastrozole
-
receptor-positive
- fsh
-
steroidogenic
- exemestane
- androstenedione
- gonadotropin
- steroidogenesis
- endometrial
- lutein
- follicular
- testicular
-
antiestrogens
-
fulvestrant
-
er-positive
-
nonsteroidal
- endometriosis
-
neoadjuvant
-
preoptic
-
third-generation
-
hormone-dependent
-
follicle-stimulating
- gnrh
-
estrogen-dependent
- oestradiol
- dihydrotestosterone
-
premenopausal
-
mastectomy
- arthralgia
-
17beta-hydroxysteroid
-
everolimus
-
5alpha-reductase
- cyp17a1
- raloxifene
- medicine
-
virilization
- progestin
-
her2-negative
Reaction
Synonyms
AROM, Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom
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medicine
comparison of cerebrocortical microvascular responses to the endothelium-dependent vasodilator ACh between male and female wild-type and aromatase knockout (ArKO) mice. Wild-type female mice have significantly greater responses to ACh compared with wild-type males, which is associated with higher aromatase expression in female compared with male cerebral vessels
medicine
in an animal model of familial Amyotrophic lateral sclerosis, i.e. copper-zinc superoxide dismutase-1-G93A transgenic mice, the motor neurons in the spinal anterior horn express aromatase under normal and nearly normal (pre-symptomatic stage) conditions. After disease onset, astrocytes begin to express aromatase. The total level of aromatase expression decreases with disease progression
medicine
increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice
medicine
allelic variants of CYP19A1 when present with a variant form of cytochrome P450 oxidoreductase POR may show different activities, and combined effects of natural variations in both the enzymes should be considered when genetic data are available
medicine
in the trophoblast choriocarcinoma cell line, JEG-3, the expression of let-7g microRNA is downregulated, but upregulated in primary term trophoblast. Aromatase is upregulated in JEG-3 cells but downregulated in primary trophoblast. Let-7g antagomirs and mimics increase and decrease aromatase expression, respectively, and Let-7g directly targets the 3'-untranslated region of CYP19A1 mRNAlet-7g antagomirs and mimics robustly increase and decrease production of estradiol, respectively
medicine
phenolic endocrine-disrupting compounds DDT, methoxychlor, benzophenone-2, bisphenol A, bisphenol S, 4-phenylphenol and n-butylparaben upregulate aromatase mRNA expression, increase aromatase activity, significantly increase the aromatase-induced biosynthesis of 17beta-estradiol, and increase ERalpha positive breast cell proliferation
medicine
tumor-associated stroma tissues display high aromatase activities. High progesterone receptor intensity levels decrease this activity level. Tumor tissue specific aromatase activity levels of postmenopausal patients' tend to be lower compared to healthy premenopausal subjects'. Low aromatase activity in tumor tissues is associated with low grade and late stage cancers