1.14.11.79: protein-L-histidine (3S)-3-hydroxylase
This is an abbreviated version!
For detailed information about protein-L-histidine (3S)-3-hydroxylase, go to the full flat file.
Reaction
Synonyms
C14orf169, MAPJD, MDIG, MINA, MINA53, NO52, NO66, protein histidyl hydroxylase, RIOX1, RIOX2
ECTree
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General Information
General Information on EC 1.14.11.79 - protein-L-histidine (3S)-3-hydroxylase
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evolution
physiological function
MINA53 belongs to a group of JmjC 2OG-oxygenases that does not contain other obvious functional domains
evolution
NO66 belongs to a group of JmjC 2OG-oxygenases that does not contain other obvious functional domains
enzyme catalyzes the hydroxylation of L-histidine residues in the 60S ribosomal protein Rpl8. Also catalyzes histone L-lysine demethylation activities, demethylates histone H3 residues H3K4me and H3K36me, i.e. activities of ECs 1.14.11.67 and 1.14.11.27, respectively
physiological function
enzyme catalyzes the hydroxylation of L-histidine residues in the 60S ribosomal protein Rpl8. Also catalyzes histone L-lysine demethylation activities, demethylates histone H3 residues H3K9me3, i.e. activity of EC 1.14.11.66
physiological function
NO66 hydroxylation reaction serves to properly orientate the 28S rRNA in the vicinity of the peptidyl transferase center