1.14.11.79: protein-L-histidine (3S)-3-hydroxylase
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For detailed information about protein-L-histidine (3S)-3-hydroxylase, go to the full flat file.
Reaction
Synonyms
C14orf169, MAPJD, MDIG, MINA, MINA53, NO52, NO66, protein histidyl hydroxylase, RIOX1, RIOX2
ECTree
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Application on EC 1.14.11.79 - protein-L-histidine (3S)-3-hydroxylase
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medicine
MINA53 is overexpressed in multiple cancer types, blocking MINA53 expression limits the proliferative capacity of several tumor cell lines in vitro. MINA53 acts as an immuno-modulator
medicine
NO66 inhibits the ability of Osterix to drive osteoblast-specific gene transcription. Overexpression of NO66 is sufficient to suppress the transactivation domain of Osterix. Mesenchymal-specific ablation of NO66 increases the expression of genes that promote bone growth and development in mice