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1.13.11.87: endo-cleaving rubber dioxygenase

This is an abbreviated version!
For detailed information about endo-cleaving rubber dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.87

Reaction

Cleavage of cis-1,4-polyisoprene polymers into a mixture of compounds, including a C20 compound ((4Z,8Z,12Z,16Z,20Z,24Z)-4,8,12,16,20,24-hexamethyl-28-oxononacosa-4,8,12,16,20,24-hexaenal), a C25 compound ((4Z,8Z,12Z,16Z,20Z)-4,8,12,16,20-pentamethyl-24-oxopentacosa-4,8,12,16,20-pentaenal), a C30 compound ((4Z,8Z,12Z,16Z)-4,8,12,16-tetramethyl-20-oxohenicosa-4,8,12,16-tetraenal), and larger isoprenologes such as C35, C40, C45, and higher analogues =

Synonyms

GPOL_174p00150, GPOL_c48310, latex clearing protein, latex-clearing protein, Lcp, Lcp protein, Lcp1, lcp1VH2, Lcp2, lcp2VH2, LcpK30, polyisoprene-cleaving rubber oxygenase, roxA, RoxB, rubber oxidizing protein, rubber oxygenase, rubber oxygenase B

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.87 endo-cleaving rubber dioxygenase

Engineering

Engineering on EC 1.13.11.87 - endo-cleaving rubber dioxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H198A
mutant protein is stable, contains no heme group and is inactive
H203A
mutant enzyme reveals wild-type properties
H232A
mutant enzyme reveals wild-type properties
H259A
mutant enzyme reveals wild-type properties
H266A
mutant enzyme reveals wild-type properties
K167A
specific activity of polyisoprene oxidation is reduced to 20%, the product spectrum is unchanged
K167H
specific activity of polyisoprene oxidation is reduced to 12%, the product spectrum is unchanged
R164A
R195A
mutant enzyme is colorless and instable
R202A
mutant enzyme is colorless and instable
T168A