EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.3.2.26 | Abortion, Spontaneous |
27901130 |
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans. |
causal interaction
therapeutic application
unassigned |
3
2
0 |
| 2.3.2.26 | Acquired Immunodeficiency Syndrome |
30854719 |
Distinguishing the optimal binding mechanism of an E3 ubiquitin ligase: Covalent versus noncovalent inhibition. |
unassigned |
0 |
| 2.3.2.26 | Acute Kidney Injury |
34061176 |
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 2.3.2.26 | Adenocarcinoma |
25395181 |
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis. |
causal interaction
diagnostic usage
unassigned |
3
1
0 |
| 2.3.2.26 | Adenocarcinoma |
28423617 |
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
4
0 |
| 2.3.2.26 | Adenocarcinoma of Lung |
21750651 |
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
3 |
| 2.3.2.26 | Adenocarcinoma of Lung |
21967197 |
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells. |
causal interaction
ongoing research
unassigned |
1
2
0 |
| 2.3.2.26 | Adenocarcinoma of Lung |
29271375 |
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
1
4
0 |
| 2.3.2.26 | Adenocarcinoma of Lung |
29455656 |
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
4 |
| 2.3.2.26 | Adenocarcinoma of Lung |
30026863 |
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
4 |
